1-(3,5-bis-dimethoxytrityl-cis-cyclohexanetriol)succinic acid | 245662-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-(3,5-bis-dimethoxytrityl-cis-cyclohexanetriol)succinic acid
• CAS: 245662-24-2
• 化学式: C₅₂H₅₂O₁₀
• 分子量: 836.979
• InChiKey: ZJMIKTOAIJVDHL-ALJGMXIHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-(3,5-bis-dimethoxytrityl-cis-cyclohexanetriol)succinic acid 、 三乙胺 以 甲醇 、 二氯甲烷 为溶剂， 生成 1-(3,5-bis-dimethoxytrityl-cis-cyclohexanetriol)succinic acid triethylammonium salt
  参考文献：
  名称：

  WO2008/73959

  摘要：

  公开号：
• 作为产物：
  描述：

  丁二酸酐 、 cis-3,5-bis-dimethoxytrityloxy-cyclohexane-1-ol 在 4-二甲氨基吡啶 作用下， 以 吡啶 为溶剂， 生成 1-(3,5-bis-dimethoxytrityl-cis-cyclohexanetriol)succinic acid
  参考文献：
  名称：

  Impact of Nature and Length of Linker Incorporated in Agonists on Toll-Like Receptor 9-Mediated Immune Responses

  摘要：

  Oligodeoxynucleotides containing unmethylated CpG motifs act as ligands of Toll-like receptor 9 (TLR9). We previously reported a novel class of TLR9 agonists, referred to as immune-modulatory oligonucleotides (IMOs), in which two 11-mers of the same sequence are attached via their 3'-ends through a 1,2,3-propanetriol linker and contain a synthetic immune-stimulatory motif, Cp7-deaza-dG. In the present study, we have examined the impact of length, nature, and stereochemistry of the linker incorporated in agonists for TLR9 activation. The new linkers studied include (S)-(-)-1,2,4-butanetriol, 1,3,5-pentanetriol, cis,cis-1,3,5-cyclohexanetriol, cis,trans-1,3,5-cyclohexanetriol, 1,3,5-tris(2-hydroxy-ethyl)isocyanurate, tetraethyleneglycol, and hexaethyleneglycol in place of 1,2,3-propanetriol linker. Agonists with various linkers are studied for TLR9-mediated immune responses in HEK293 cells, human cell-based assays, and in vivo in mice. Results of these studies suggest that C3-C5 linkers, 1,2,3-propanetriol, (S)-(-)-1,2,4-butanetriol, or 1,3,5-pentanetriol, are optimal for stimulation of TLR9-mediated immune responses. Rigid C3 linkers with different stereochemistry have little effect on immune stimulation, while linkers longer than C5 reduced TLR9-mediated immune stimulation.

  DOI：

  10.1021/jm100177p