tripropylsilanol | 17888-60-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tripropylsilanol
• 英文别名: hydroxy(tripropyl)silane
• CAS: 17888-60-7
• 化学式: C₉H₂₂OSi
• 分子量: 174.359
• InChiKey: IOANYFLVSWZRND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  tripropylsilanol 在 Na 作用下， 生成 Sodium;oxido(tripropyl)silane
  参考文献：
  名称：

  Pape, C., Chemische Berichte, 1881, vol. 14, p. 1872 - 1876

  摘要：

  DOI：
• 作为产物：
  描述：

  三丙基氯硅烷 在 吡啶 、 乙醚 、 水 作用下， 生成 tripropylsilanol
  参考文献：
  名称：

  Hypoxia and an Angiogenic Response in the Partially Obstructed Rat Bladder

  摘要：

  Previous molecular and blood flow studies performed on animal models of partial bladder outlet obstruction (PBOO) caused us to propose that bladder hypoxia/ischemia was a significant effector of the cellular and functional changes that occur in the bladder as a result of this condition. To confirm the occurrence of hypoxia in the partially obstructed bladder, we obtained rat bladders at increasing intervals following PBOO and measured biomarkers of hypoxia (intracellular formation of hypoxyprobe-1 adducts and expression of hypoxia inducible factor-1alpha [HIF-1alpha] protein) and whether such hypoxia might elicit an angiogenic response in the tissue. Rats receiving PBOO or controls were treated with hypoxyprobe-1 at increasing intervals subsequent to surgery and their bladders were sectioned and immunostained using an antibody that detects hypoxyprobe-1 adducts. Control rat bladders were unstained, whereas intense, but regionally restricted, hypoxyprobe-1 immunostaining was detected in all obstructed bladders in a unique pattern that changed over time. Proteins were extracted from bladders removed from similarly treated rats and were analyzed for the expression of the HIF-1alpha protein as well as for expression of angiogenic regulatory factors (vascular endothelial growth factor, angiopoietin-1, and endostatin) using Western blotting techniques. HIF-1alpha protein was not expressed in control bladders, however, the protein was highly up-regulated over the 2-week period after PBOO. Likewise, the expression of vascular endothelial growth factor (a downstream target of HIF-1alpha action) and angiopoietin-1 was also up-regulated in obstructed bladders confirming an angiogenic response to this hypoxia. Enigmatically, however, expression of the antiangiogenic molecule endostatin was also up-regulated by chronic PBOO. These results further support the concept that hypoxia is involved in the cellular remodeling as well as in the progressive functional impairment exhibited by the urinary bladder after PBOO.

  DOI：

  10.1097/01.lab.0000021135.87203.92

文献信息

• Silylation of Alcohols, Phenols, and Silanols with Alkynylsilanes - an Efficient Route to Silyl Ethers and Unsymmetrical Siloxanes
  作者：Krzysztof Kuciński、Hanna Stachowiak、Grzegorz Hreczycho

  DOI：10.1002/ejoc.202000573

  日期：2020.7.15

  Alkynylsilanes – a missing piece of different silylation agents, can serve as valuable substrates in the O‐silylation through a dealkynative coupling with alcohols or silanols. The described approach displays a whole array of advantages in terms of green chemistry and is a promising alternative to existing methodologies.

  炔基硅烷–缺少的一种不同的甲硅烷基化剂，可以通过与醇或硅烷醇的脱炔基偶联而成为O-硅烷化中的重要底物。所描述的方法在绿色化学方面显示了一系列优势，并且是现有方法的有希望的替代方法。
• Catalysis by cationic oxorhenium(v): hydrolysis and alcoholysis of organic silanes
  作者：Rex A. Corbin、Elon A. Ison、Mahdi M. Abu-Omar

  DOI：10.1039/b822783g

  日期：——

  The cationic [2-(2'-hydroxyphenyl)-2-oxazolinato(-2)]oxorhenium(v) complex promotes oxidative dehydrogenation of organosilanes with water and alcohols in a catalytic manner to give excellent yields of silanols and silyl ethers, respectively. The reactions proceed conveniently under ambient and open-flask conditions with low catalyst loading (

  阳离子[2-（2'-羟基苯基）-2-恶唑啉基（-2）] or（v）配合物以催化方式促进有机硅烷与水和醇的氧化脱氢，分别获得优异的硅烷醇和甲硅烷基醚收率。反应可在环境和开瓶条件下以较低的催化剂负载量方便地进行（
• Gold nanoparticles supported on the periodic mesoporous organosilica SBA-15 as an efficient and reusable catalyst for selective oxidation of silanes to silanols
  作者：Lina Ma、Wenguang Leng、Yaopeng Zhao、Yanan Gao、Hongdong Duan

  DOI：10.1039/c3ra47047d

  日期：——

  Gold nanoparticles are confined and stabilized within the channels of SBA-15 through the poly(ionic liquid) brushes that are anchored onto the pore walls of SBA-15. The supported gold catalyst exhibited remarkably high catalytic activities for selective oxidation of silanes into silanols using water as an oxidant without the use of organic solvents.

  金纳米颗粒通过固定在SBA-15孔壁上的聚离子液体刷被限制并稳定在SBA-15的通道内。负载的金催化剂对于使用水作为氧化剂而不使用有机溶剂将硅烷选择性氧化为硅烷醇表现出极高的催化活性。
• Cobalt-Catalyzed Selective Synthesis of Disiloxanes and Hydrodisiloxanes
  作者：Sandip Pattanaik、Chidambaram Gunanathan

  DOI：10.1021/acscatal.9b00305

  日期：2019.6.7

  independent experiments confirmed the catalytic oxidation of silane to silanol, and further dehydrocoupling processes are involved in syntheses of symmetrical siloxanes, cyclotetrasiloxanes, and siloxane cage compounds, whereas the unsymmetrical monohydrosiloxane syntheses from silanes and silanols proceeded via dehydrogenative coupling reactions. Overall these cobalt-catalyzed oxidative coupling reactions

  分别从硅烷和二氢硅烷与水的反应中获得对称的硅氧烷和环四硅氧烷的选择性合成，并且该反应由NNN H t Bu钴（II）钳形配合物催化。有趣的是，当苯硅烷用水进行催化时，获得了由12个硅和18个氧中心组成的硅氧烷笼，反应明显进行，释放出3当量的分子氢（36 H 2）在温和的实验条件下。在硅烷与不同的硅烷醇反应后，通过钴催化实现了高选择性和受控的高级单氢硅氧烷和二甲氧基单氢硅烷的合成。释放的分子氢是在所有这些转化中观察到的唯一副产物。机理研究表明，反应是通过均质途径发生的。动力学和独立实验证实了硅烷催化氧化为硅烷醇的过程，并且进一步的脱氢偶联过程还涉及对称硅氧烷，环四硅氧烷和硅氧烷笼型化合物的合成，而硅烷和硅烷醇的不对称一氢硅氧烷则通过脱氢偶联反应进行合成。总体而言，这些钴催化的氧化偶联反应基于Si–H，Si–OH，和硅烷，硅烷醇和水的O–H键活化。建议使用由Co（II）中间体组成的催化循环。
• A Flexible Nonporous Heterogeneous Catalyst for Size-Selective Oxidation through a Bottom-Up Approach
  作者：Noritaka Mizuno、Sayaka Uchida、Keigo Kamata、Ryo Ishimoto、Susumu Nojima、Koji Yonehara、Yasutaka Sumida

  DOI：10.1002/anie.201005275

  日期：2010.12.17

  Size does matter: The nonporous tetra‐n‐butylammonium salt of silicodecatungstate, synthesized through a bottom‐up approach, heterogeneously catalyzes the size‐selective oxidation of various organic compounds, including olefins, sulfides, and organosilanes, with aqueous H2O2 in ethyl acetate. The catalyst can be easily separated by filtration and reused several times with retention of high catalytic

  大小确实很重要：通过自下而上的方法合成的无孔硅酸四硅烷基四正丁铵盐，可在H 2 O 2水溶液中以非均相催化催化各种有机化合物的尺寸选择氧化，包括烯烃，硫化物和有机硅烷。乙酸乙酯。可以通过过滤容易地分离催化剂，并在保持高催化活性的情况下重复使用数次。