1-acetyl-piperidine-3-carboxylic acid ethyl ester | 2637-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-acetyl-piperidine-3-carboxylic acid ethyl ester
• 英文别名: 1-Acetyl-piperidin-3-carbonsaeure-ethylester；Ethyl-1-acetyl-piperidin-3-carboxylat；Ethyl 1-acetylpiperidine-3-carboxylate
• CAS: 2637-75-4
• 化学式: C₁₀H₁₇NO₃
• mdl: MFCD02862111
• 分子量: 199.25
• InChiKey: QPSYWOLGKVKKHD-UHFFFAOYSA-N

物化性质

• 沸点：
  110 °C(Press: 0.05 Torr)
• 密度：
  1.089±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  原乙酸三乙酯 、 3-哌啶甲酸 以 甲苯 为溶剂， 反应 24.0h， 以94%的产率得到1-acetyl-piperidine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Concurrent esterification and N-acetylation of amino acids with orthoesters: a useful reaction with interesting mechanistic implications

  摘要：

  The concurrent esterification and N-acetylation of amino acids has been studied with triethyl orthoacetate (TEOA) and triethyl orthoformate (TEOF). In a surprising finding, only 1 equiv of TEOA in refluxing toluene was necessary to convert L-proline and L-phenylalanine into the corresponding N-acetyl ethyl esters in good yield. The same transformation using TEOF was not effective. Stereochemical outcome and stoichiometric studies as well as structural variation of the amino acids in this reaction provided unexpected mechanistic insight. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.081

文献信息

• PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS
  申请人：Chen L. Yuhpyng

  公开号：US20070270474A1

  公开（公告）日：2007-11-22

  The invention provides compounds of Formula I: wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 and A are as defined. Compounds of formula I have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

  该发明提供了I式化合物：其中R1、R2、R3、R4、R6、R7、R8和A的定义如下。 I式化合物具有抑制Aβ肽的产生活性。该发明还提供了包含I式化合物的药物组合物和治疗哺乳动物疾病的方法，例如阿尔茨海默病。
• Novel Indolin-2-one Derivatives, Their Preparation and the Pharmaceutical Compositions Comprising Them
  申请人：FOULON Loic

  公开号：US20070203184A1

  公开（公告）日：2007-08-30

  The present invention relates to novel indolin-2-one derivatives of formula: to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.

  本发明涉及公式为的新型吲哚啉-2-酮衍生物、其制备方法以及包含它们的药物组合物。这些化合物具有与催产素受体的亲和力。
• US7238721B2
  申请人：——

  公开号：US7238721B2

  公开（公告）日：2007-07-03
• US7468371B2
  申请人：——

  公开号：US7468371B2

  公开（公告）日：2008-12-23
• US7488752B2
  申请人：——

  公开号：US7488752B2

  公开（公告）日：2009-02-10