2,4,6-Tris(hydroxymethyl)1,3,5-triazine | 35045-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2,4,6-Tris(hydroxymethyl)1,3,5-triazine
• 英文别名: C,C',C''-[1,3,5]triazine-2,4,6-triyl-tris-methanol；2,4,6-Trihydroxymethyl-s-triazine；[4,6-bis(hydroxymethyl)-1,3,5-triazin-2-yl]methanol
• CAS: 35045-13-7
• 化学式: C₆H₉N₃O₃
• 分子量: 171.156
• InChiKey: KCUIKRQEXXDCNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  99.4
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,4,6-Tris(hydroxymethyl)1,3,5-triazine 、 异氰酸甲酯 在 tin(IV) 2-ethylhexanoate 作用下， 以 吡啶 为溶剂， 以91%的产率得到Tris(N-methylcarbamic ester)2,4,6-tris(hydroxymethyl)1,3,5-triazine
  参考文献：
  名称：

  Synthesis and antibradykinin properties of pyridine and triazine analogs of parmidine

  摘要：

  DOI：

  10.1007/bf00758534
• 作为产物：
  描述：

  1,3,5-三嗪-2,4,6-三甲酸三乙酯 在 sodium borohydrid 、 无水氯化钙 作用下， 以 二氯甲烷 为溶剂， 生成 2,4,6-Tris(hydroxymethyl)1,3,5-triazine
  参考文献：
  名称：

  Compounds having a plurality of nitrogenous substitutents

  摘要：

  具有以下公式的新化合物： 其中所述组分变量在此处定义。这些化合物被构建为包括一个中心芳香、脂肪或杂环环系统。连接到中心环系统的是两个具有氮基团的线性基团，这些基团经过化学官能团衍生。环系统可以包括进一步的氮基团，可以作为环原子或连接到环上的侧链基团，这些基团也可以经过化学官能团衍生。化学官能团的总体赋予这些化合物某些构象和其他性质。根据本发明的某些实施例，利用化学官能团和氮基团的排列组合制备这类化合物的文库，以在文库中构建复杂性。

  公开号：

  US06329523B1

文献信息

• Nitrogenous macrocyclic compounds
  申请人：Isis Pharmaceuticals, Inc.

  公开号：US06107482A1

  公开（公告）日：2000-08-22

  Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or more ring systems thereby forming a large cyclic structure. Located in each bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the macrocyclic compounds. In accordance with certain embodiments of the invention, libraries of such macrocyclic compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.

  新型大环化合物被构建成包含至少一个环系统打断的大环结构。每个打断的环系统包括两个桥头原子。桥头原子与一个或多个桥连接，连接一个或多个环系统，从而形成一个大环结构。每个桥中都含有两个或更多的氮基团，这些氮基团经过化学官能团衍生。环系统可以包括进一步的氮基团，可以是环原子，也可以是连接到环上的侧链基团。这些也可以经过化学官能团衍生。化学官能团的总体赋予大环化合物特定的构象和其他性质。根据发明的某些实施例，利用化学官能团和氮基团的排列组合制备这种大环化合物的文库，以在文库中构建复杂性。
• Substituted heterocyclic compounds
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06077954A1

  公开（公告）日：2000-06-20

  Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear groups having nitrogenous moieties that are derivatized with chemical functional groups. The ring system can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring, that may also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the these compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the libraries.

  具有以下结构式的新化合物：##STR1## 其中所述变量在此处定义。这些化合物被构建为包括一个中心芳香、脂肪或杂环环系统。连接到中心环系统的是两个线性基团，其具有氮基团，这些氮基团经过化学官能团衍生。环系统可以包括进一步的氮基团，可以作为环原子或连接到环上的侧链基团，这些氮基团也可以经过化学官能团衍生。化学官能团的总体赋予这些化合物某些构象和其他性质。根据本发明的某些实施例，利用化学官能团和氮基团的排列组合制备这类化合物的文库，以在文库中构建复杂性。
• Halogen-free flame retardant polyester
  申请人：Wit De Gerrit

  公开号：US20060074155A1

  公开（公告）日：2006-04-06

  Novel polyester composition comprising a polyester, wherein said polyester comprises structural units derived from substituted or unsubstituted diacid or diester, a substituted or unsubstituted diol; a phosphorus containing compound and at least one selected from a stabilizer and an organic compound comprising at least one functional group is been disclosed. In addition methods for the preparation of the polyester composition and articles derived from said composition is disclosed.

  本发明涉及一种新型聚酯组合物，包括聚酯和以下组分：由取代或未取代的二酸或二酯衍生的结构单元，取代或未取代的二元醇，含磷化合物以及至少选择自稳定剂和含有至少一个官能团的有机化合物之一。此外，本发明还涉及制备该聚酯组合物的方法以及从该组合物衍生的物品。
• Macrocyclic compounds having nitrogen-containing linkages
  申请人：Isis Pharmaceuticals, Inc.

  公开号：US06207826B1

  公开（公告）日：2001-03-27

  Novel macrocyclic compounds are constructed to include a ring or ring system having two bridgehead atoms with a bridge extending between the bridgehead atoms. Located in at least the bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring or ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.

  新型大环化合物被构建，包括一个具有两个桥头原子和桥梁的环或环系统延伸在桥头原子之间。至少在桥梁中，有两个或更多的含氮基团被化学官能团衍生。环或环系统可以包括进一步的含氮基团，作为环原子或附着在环上的吊坠基团。这些也可以被化学官能团衍生。化学官能团的总体赋予化合物某些构象和其他性质。根据发明的某些实施方式，利用化学官能团和含氮基团的排列组合来构建复杂性的化合物库。
• Compounds having a plurality of nitrogenous substituents
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06197965B1

  公开（公告）日：2001-03-06

  Novel compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear groups having nitrogenous moieties that are derivatized with chemical functional groups. The ring system can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring, that may also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the these compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the libraries.

  新颖的化合物被构建成包括一个中心芳香、脂肪族或杂环环系统。连接到中心环系统的是两个线性基团，具有氮基团，这些氮基团被衍生出化学官能团。环系统可以包括进一步的氮基团，无论是作为环原子还是附着在环上的垂饰基团，这些氮基团也可以被衍生出化学官能团。化学官能团的总体赋予这些化合物某些构象和其他性质。根据本发明的某些实施例，利用化学官能团和氮基团的排列组合来构建复杂性，制备这种化合物的库。