diethyl allylphosphonite | 90196-57-9

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: diethyl allylphosphonite
• 英文别名: Allylphosphonigsaeure-diethylester；Diethoxy(prop-2-enyl)phosphane
• CAS: 90196-57-9
• 化学式: C₇H₁₅O₂P
• 分子量: 162.169
• InChiKey: GNWOUVQNZQPHKN-UHFFFAOYSA-N

物化性质

• 沸点：
  167.8±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  diethyl allylphosphonite 在 sulfur 作用下， 生成 O,O-diethyl allylphosphonothioate
  参考文献：
  名称：

  Razumov,A.I. et al., Journal of general chemistry of the USSR, 1964, vol. 34, p. 1863 - 1866

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙基亚磷酰氯 生成 diethyl allylphosphonite
  参考文献：
  名称：

  CAMPBELL, M. M.;CARRUTHERS, N. I.;MICKEL, S. J.;WINTON, P. M., J. CHEM. SOC. CHEM. COMMUN., 1984, N 3, 200

  摘要：

  DOI：

文献信息

• ANTI-CANCER PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20100022467A1

  公开（公告）日：2010-01-28

  The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗癌化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• New substituted azetidinones as anti-inflammatory and antidegenerative agents
  申请人：MERCK & CO. INC.

  公开号：EP0505095A2

  公开（公告）日：1992-09-23

  New substituted azetidinones of the general formula (A), which have been found to be potent elastase inhibitors and thereby useful as anti-inflammatory and antidegenerative agents, are described.

  本文描述了通式（A）的新取代氮杂环丁酮，发现它们是有效的弹性蛋白酶抑制剂，因此可用作抗炎和抗退行性药物。
• Liorber,B.G.; Razumov,A.I., Journal of general chemistry of the USSR, 1964, vol. 34, p. 1867 - 1870
  作者：Liorber,B.G.、Razumov,A.I.

  DOI：——

  日期：——
• 1-Phosphacephalosporin. I. Synthesis of racemic 7-unsubstituted-1-phosphadethia-3-cephem 1-oxides
  作者：Hisao Satoh、Teruji Tsuji

  DOI：10.1016/s0040-4039(01)81158-8

  日期：1984.1
• CROSS-METATHESIS REACTION OF FUNCTIONALIZED AND SUBSTITUTED OLEFINS USING GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS METATHESIS CATALYSTS
  申请人：California Institute Of Technology

  公开号：US20140288319A1

  公开（公告）日：2014-09-25

  The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.