5-Chloro-6-phenyl-3-pyridin-2-yl-[1,2,4]triazine | 126542-95-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 5-Chloro-6-phenyl-3-pyridin-2-yl-[1,2,4]triazine
• 英文别名: 5-Chloro-6-phenyl-3-pyridin-2-yl-1,2,4-triazine
• CAS: 126542-95-8
• 化学式: C₁₄H₉ClN₄
• 分子量: 268.705
• InChiKey: PBTQWNREAONKRA-UHFFFAOYSA-N

物化性质

• 沸点：
  487.5±53.0 °C(Predicted)
• 密度：
  1.311±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.56
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  5-Chloro-6-phenyl-3-pyridin-2-yl-[1,2,4]triazine 以 1,4-二氧六环 为溶剂， 反应 7.0h， 生成 4-hex-5-ynyl-6-phenyl-3-pyridin-2-yl-1,2,4-triazin-5-one
  参考文献：
  名称：

  Neunhoeffer, Hans; Reichel, Diethard; Cullmann, Birgit, Liebigs Annalen der Chemie, 1990, # 7, p. 631 - 640

  摘要：

  DOI：
• 作为产物：
  描述：

  6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5(4H)-one 在 五氯化磷 作用下， 以 xylene 为溶剂， 反应 18.0h， 生成 5-Chloro-6-phenyl-3-pyridin-2-yl-[1,2,4]triazine
  参考文献：
  名称：

  Neunhoeffer, Hans; Reichel, Diethard; Cullmann, Birgit, Liebigs Annalen der Chemie, 1990, # 7, p. 631 - 640

  摘要：

  DOI：

文献信息

• 유기 화합물 및 이를 이용한 유기 전계 발광 소자
  申请人：Solus Advanced Materials co., Ltd. 솔루스첨단소재 주식회사(120190660630) Corp. No ▼ 214911-0058927BRN ▼668-81-01406

  公开号：KR20210078631A

  公开（公告）日：2021-06-29

  본 발명은 신규한 유기 화합물 및 이를 이용한 유기 전계 발광 소자에 대한 것으로, 보다 상세하게는 발광능, 전자수송능, 전기화학적 안정성, 열적 안정성 등이 우수한 유기 화합물 및 이를 하나 이상의 유기물층에 포함함으로써 발광효율, 구동 전압, 수명 등의 특성이 향상된 유기 전계 발광 소자에 대한 것이다.

  本发明涉及一种新的有机化合物及其用于有机电致发光器件，更详细地说，涉及一种有机化合物，具有出色的发光性能、电子传输性能、电化学稳定性、热稳定性等特性，并通过将其包含在一个或多个有机层中，以提高发光效率、驱动电压、寿命等特性的有机电致发光器件。
• Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway
  作者：Jimmy R. Theriault、Andrew S. Felts、Brittney S. Bates、Jose R. Perez、Michelle Palmer、Shawn R. Gilbert、Eric S. Dawson、Julie L. Engers、Craig W. Lindsley、Kyle A. Emmitte

  DOI：10.1016/j.bmcl.2011.11.077

  日期：2012.1

  Hypoxia and ischemia are linked to several serious public health problems that affect most major organ systems. Specific examples include diseases of the cardiovascular, pulmonary, renal, neurologic, and musculoskeletal systems. The most significant pathway for cellular response to hypoxia is the hypoxia inducible factor (HIF) pathway. HIFs are transcription factors responsible for the activation of genes which encode proteins that mediate adaptive responses to reduced oxygen availability. A high-throughput cell-based HIF-mediated gene reporter screen was carried out using the NIH's Molecular Libraries Small Molecule Repository to identify activators of the HIF pathway. This communication describes the subsequent medicinal chemistry optimization of a triazine scaffold that led to the identification of the new molecular probe ML228. A discussion of HIF activation SAR within this chemotype as well as detailed in vitro characterization of the probe molecule is presented here. (C) 2011 Elsevier Ltd. All rights reserved.
• NEUNHOEFFER, HANS;REICHEL, DIETHARD;CULLMANN, BIRGIT;REHN, INGRID, LIEBIGS ANN. CHEM.,(1990) N, C. 631-460
  作者：NEUNHOEFFER, HANS、REICHEL, DIETHARD、CULLMANN, BIRGIT、REHN, INGRID

  DOI：——

  日期：——