(E)-1-(4-isocyanatophenyl)-2-(4-nitrophenyl)diazene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: (E)-1-(4-isocyanatophenyl)-2-(4-nitrophenyl)diazene
• 英文别名: 4-isocyanato-4'-nitroazobenzene；4-isocyanato-4'-nitrobenzene
• 化学式: C₁₃H₈N₄O₃
• 分子量: 268.232
• InChiKey: YLHKYJAZLJOBPZ-FOCLMDBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.29
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (E)-1-(4-isocyanatophenyl)-2-(4-nitrophenyl)diazene 在 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 1-(5-Amino-pentyl)-3-[4-(4-nitro-phenylazo)-phenyl]-urea
  参考文献：
  名称：

  Molecular Recognition in a Thermoplastic Elastomer

  摘要：

  Selective incorporation of bisurea guests in thermoplastic elastomers with poly (tetrahydronfuran) soft blocks and bisurea containing hard blocks is observed when the distances between the urea groups of host and guest match. The incorporation leads to significant modulation of mechanical properties. With bisurea-functionalized dyes as guests, a strong difference in extractability by detergent solution was shown between dyes differing by just one methylene unit between urea groups. Upon elongation of elastomer films, strong differences in alignability of matching and nonmatching dyes were observed.

  DOI：

  10.1021/ja0451160
• 作为产物：
  描述：

  三光气 、 分散橙 3 生成 (E)-1-(4-isocyanatophenyl)-2-(4-nitrophenyl)diazene
  参考文献：
  名称：

  Visible Colorimetric Fluoride Ion Sensors

  摘要：

  Five new urea derivative naphthalene compounds were synthesized by a reaction of 1,8-diaminonaphthalene and the corresponding isocyanates and showed a distinct color change only when treated with fluoride ions.

  DOI：

  10.1021/ol0507470

文献信息

• A ferrocenyl-guanidine derivative as a highly selective electrochemical and colorimetric chemosensor molecule for acetate anions
  作者：Antonia Sola、Alberto Tárraga、Pedro Molina

  DOI：10.1039/c2dt30632h

  日期：——

  A highly preorganized chemosensor molecule 1 based on a ferrocenyl-guanidine decorated with a chromogenic aryl azo moiety recognizes the acetate anion in acetonitrile solution. At first, receptor 1 underwent two-step oxidation events. Initially, oxidation of 1 occurs at the Fe(II) centre (Ep = 440 mV) to form a ferrocenium species, followed by fast electron transfer from the guanidine moiety of the receptor to the Fe(III) centre with concomitant generation of an Fe(II) species with a radical cation centred at the nitrogen atom. In the second step, the radical cation species formed should undergo electrochemical oxidation at higher potential (Ep = 830 mV). This assumption is supported by spectroelectrochemical studies. A remarkable cathodic shift (182 mV) of the ferrocene/ferrocenium oxidation peak (Ep = 440 mV) and a progressive red-shift (Δλ = 30 nm) of the low energy band are observed in its absorption spectrum upon complexation of receptor 1 with the acetate anion. This change in the absorption spectrum is accompanied by a colour change from yellow to orange, which can be used for the “naked-eye” detection of this anion. Its monoprotonated form is able to selectively sense the less basic Cl−, Br−, NO3−, and HSO4− anions: the oxidation redox peak at Ep = 865 mV is cathodically shifted (107–182 mV).

  高度预组织化的化学传感器分子 1 以二茂铁基胍为基础，装饰有可发色的芳基偶氮分子，可识别乙腈溶液中的乙酸阴离子。起初，受体 1 经历了两步氧化过程。首先，1 在铁(II)中心发生氧化（Ep = 440 mV），形成一种铁络合物，然后电子从受体的胍基快速转移到铁(III)中心，同时产生一种以氮原子为中心带有自由基阳离子的铁(II)物质。在第二步中，形成的自由基阳离子物种应在较高的电位（Ep = 830 mV）下进行电化学氧化。这一假设得到了光谱电化学研究的支持。受体 1 与醋酸阴离子络合后，二茂铁/二茂铁氧化峰（Ep = 440 mV）发生了明显的阴极移动（182 mV），其吸收光谱中的低能带也逐渐发生了红移（Δλ = 30 nm）。吸收光谱的这种变化伴随着从黄色到橙色的颜色变化，可用于 "肉眼 "检测这种阴离子。它的单质子化形式能够选择性地感应碱性较弱的 Cl-、Br-、NO3- 和 HSO4-阴离子：Ep = 865 mV 处的氧化还原峰会发生阴极移动（107-182 mV）。
• DEVICE FOR CARTILAGE REPAIR
  申请人：Hermsen Egidius Gerardus Maria

  公开号：US20080262618A1

  公开（公告）日：2008-10-23

  A prosthesis device comprising a body at least partly formed from a biocompatible segmented thermoplastic elastomer having crystallized blocks, and at least one functional component which is able to reversibly bond to the crystallized blocks, wherein the elastomer has cartilage regenerative properties. A method is provided for the preparation of the biocompatible elastomer having cartilage regenerative properties, and a method for incorporating the biocompatible elastomer in a prosthesis device able to grow into cartilage.

  一种假体设备，包括至少部分由生物相容的分段热塑性弹性体制成的本体，该弹性体具有结晶块，并且至少有一个功能组件能够可逆地结合到结晶块上，其中弹性体具有软骨再生特性。提供了制备具有软骨再生特性的生物相容性弹性体的方法，以及将生物相容性弹性体纳入能够生长成软骨的假体装置的方法。
• Device for cartilage repair
  申请人：Jointsphere B.V.

  公开号：EP1985319A1

  公开（公告）日：2008-10-29

  The invention relates to a prosthesis device comprising a body at least partly formed from a biocompatible elastomer, in particular a segmented thermoplastic elastomer having crystallized blocks, and at least one functional component, which is able to chemically bond to the crystallized blocks, and has cartilage regenerative properties. The invention also relates to a method for placing a prosthesis into a joint space and/or bone structure.

  本发明涉及一种假体装置，包括至少部分由生物相容性弹性体（尤其是具有结晶块的分段热塑性弹性体）形成的主体，以及至少一种能够与结晶块化学键合且具有软骨再生特性的功能成分。本发明还涉及一种将假体植入关节间隙和/或骨结构的方法。
• 2-Dimensional Analytic Approach for Anion Differentiation with Chromofluorogenic Receptors
  作者：T. Daniel Thangadurai、N. Jiten Singh、In-Chul Hwang、Jung Woo Lee、R. Prakash Chandran、Kwang S. Kim

  DOI：10.1021/jo070791o

  日期：2007.7.1

  By linking the urea moiety at the 1,8 positions of the carbazole fragment, we synthesized host systems 1, 2, and 3 having both chromogenic and fluorogenic signaling subunits. The spectral changes in both the signaling subunits could be easily analyzed via a simple 2-dimensional (2D) analytic approach described here, which enables us to differentiate the given set of anions. Structural studies are also reported.
• DYED-HAIR-BINDING PEPTIDES AND PEPTIDE-BASED HAIR REAGENTS FOR PERSONAL CARE
  申请人：BENSON R. EDWARD

  公开号：US20090074694A1

  公开（公告）日：2009-03-19

  Peptides have been identified that bind with high affinity to dyed hair. Peptide-based hair reagents formed by coupling a dyed-hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of a dyed-hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based hair reagents or the dyed-hair-binding peptides may also be used as a protective sealant to improve color retention of dyed hair.