苯基-(4-苯基偶氮苯基)二氮烯 | 1161-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 中文名称: 苯基-(4-苯基偶氮苯基)二氮烯
• 英文名称: p-Phenylazo-azobenzol
• 英文别名: Azobenzene, 4-(phenylazo)-；phenyl-(4-phenyldiazenylphenyl)diazene
• CAS: 1161-45-1
• 化学式: C₁₈H₁₄N₄
• 分子量: 286.336
• InChiKey: QLYZYCHWGGSYBD-UHFFFAOYSA-N

物化性质

• 熔点：
  167 °C
• 沸点：
  461.0±28.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2927000090

反应信息

• 作为反应物：
  描述：

  苯基-(4-苯基偶氮苯基)二氮烯 在 双氧水 、 溶剂黄146 作用下， 生成 1.4-bis-(phenyl-ONN-azoxy)-benzene
  参考文献：
  名称：

  Angeli, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1913, vol. <5>22 I, p. 358

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 aluminium amalgam 作用下， 生成 苯基-(4-苯基偶氮苯基)二氮烯
  参考文献：
  名称：

  Angeli, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1913, vol. <5>22 I, p. 849

  摘要：

  DOI：

文献信息

• STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES
  申请人：Cook Ronald M.

  公开号：US20090259030A1

  公开（公告）日：2009-10-15

  The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

  本发明提供了一种新型固体支持体，用于合成修饰寡核苷酸的新类固体支持体以及具有在新支持体上方便合成的核酸探针。示例固体支持体包括至少通过连接剂与固体支持体结合的一个猝灭剂。各种示例实施例包括稳定双链、三链或更高级别聚集（例如，杂交）的基团，其中该发明的寡聚物是其中的一个组分的基团。固体支持体的其他组分包括稳定核酸聚集的基团，例如，插入剂、小沟结合基团、经过稳定基团修饰的碱基（例如，炔基基团和氟烷基团）和构象稳定基团，例如，如同在共同拥有的美国专利申请公开号2007/0059752中描述的那样。
• Negatively charged minor groove binders
  申请人：Lukhtanov A. Eugeny

  公开号：US20050187383A1

  公开（公告）日：2005-08-25

  The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.

  本发明提供一种带负电的小沟结合化合物，包括含有该化合物的寡核苷酸共轭物，以及使用它们的方法。本发明的带负电小沟结合化合物包括一个在生理条件下能够被电离的酸性基团。特别地，本发明的带负电小沟结合化合物包括一个结合基团，该结合基团优先结合于双链、三链或更高链的DNA、RNA、PNA或其杂交物的小沟。该结合基团包括至少一个芳基基团和一个酸性基团，该酸性基团共价连接到芳基基团的苯基部分或芳基基团的杂环部分的杂原子上。
• NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS
  申请人：EWING Gregory J.

  公开号：US20090105452A1

  公开（公告）日：2009-04-23

  Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labeled biomolecules for various molecular biology assays based on fluorescence detection.

  双重重氮基团、三芳基和芳基重氮-N-芳基苯唑啉猝灭基团，通过在离域芳基/重氮环系统中引入电子受体和电子供体取代基，可以作为标签附加到生物分子上，如多核苷酸、核苷、核苷酸和多肽。这些猝灭基团是非荧光的，可以通过任何能量转移机制（例如FRET）从荧光报告标签接受能量转移。荧光猝灭剂组合物在制备标记生物分子的过程中非常有用，用于各种基于荧光检测的分子生物学测定。
• NEGATIVELY CHARGED MINOR GROOVE BINDERS
  申请人：Lukhtanov Eugeny A.

  公开号：US20100137614A1

  公开（公告）日：2010-06-03

  The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.

  本发明提供了一种带有负电荷的小沟结合化合物，包括该化合物的寡核苷酸共轭物，并提供了使用它们的方法。本发明的带有负电荷的小沟结合化合物包括一个酸性基团，在生理条件下能够被电离。特别地，本发明的带有负电荷的小沟结合化合物包括一个结合基团，优先结合于双链、三链或更高链的DNA、RNA、PNA或其杂交物的小沟中。结合基团包括至少一个芳基基团和一个酸性基团，该酸性基团共价连接到芳基基团的苯基部分或芳基基团的杂环部分的杂原子上。
• Non-Fluorescent Quencher Compounds and Biomolecular Assays
  申请人：Ewing Gregory J.

  公开号：US20110245462A1

  公开（公告）日：2011-10-06

  Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labeled biomolecules for various molecular biology assays based on fluorescence detection.

  双重重氮基团、三芳基和芳基重氮基-N-芳基苯并咪唑猝灭基团，通过引入电子吸引和电子给予取代基来诱导离域芳基/重氮环系统的极性，当附加到生物分子如多核苷酸、核苷、核苷酸和多肽时，它们可用作标签。猝灭基团是无荧光的，并且通过任何能量转移机制（如FRET），从荧光报告标签接受能量转移。荧光猝灭组合物在制备带有猝灭标记的生物分子用于基于荧光检测的各种分子生物学测定中非常有用。