2,3-二苄氧基苯甲酸 | 102184-11-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 2,3-二苄氧基苯甲酸
• 英文名称: 2,3-Dibenzyloxybenzoic acid
• 英文别名: 2,3-dibenzoxybenzoic acid；2,3-Dibenzoyloxybenzoic acid
• CAS: 102184-11-2
• 化学式: C₂₁H₁₄O₆
• 分子量: 362.339
• InChiKey: AIGAFBHFDMNBOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3-二苄氧基苯甲酸 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 [2-Benzoyloxy-3-[4-[3-[(2,3-dibenzoyloxybenzoyl)amino]propylamino]butylcarbamoyl]phenyl] benzoate
  参考文献：
  名称：

  A simple method for the direct bis-acylation of the primary amino groups in spermidine and other linear triamines

  摘要：

  DOI：

  10.1016/s0040-4039(01)81670-1
• 作为产物：
  描述：

  苯甲酸,二羟基- 、 苯甲酸酐 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以93%的产率得到2,3-二苄氧基苯甲酸
  参考文献：
  名称：

  Modified Galacto‐ or Fuco‐Clusters Exploiting the Siderophore Pathway to Inhibit the LecA‐ or LecB‐Associated Virulence ofPseudomonas aeruginosa

  摘要：

  AbstractGalacto‐ and fuco‐clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster–pseudosiderophore conjugates were evaluated as Trojan horses to cross the outer membrane of PA by iron transport. The data suggest that glycoclusters with catechol moieties are able to hijack the iron transport, whereas those with hydroxamates showed strong nonspecific interactions. Mono‐ and tricatechol galactoclusters (G1C and G3C) were evaluated as inhibitors of infection by PA in comparison with the free galactocluster (G0). All of them exhibited an inhibitory effect between 46 to 75 % at 100 μM, with a higher potency than G0. This result shows that LecA localised in the outer membrane of PA is involved in the infection mechanism.

  DOI：

  10.1002/cbic.202000490