N2-isobutyryl-5'-O-dimethoxytrityl-2'-deoxyguanosine-3'-O-(4-cyanomethylbenzyl)-N,N-diisopropylphosphoramidite

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N2-isobutyryl-5'-O-dimethoxytrityl-2'-deoxyguanosine-3'-O-(4-cyanomethylbenzyl)-N,N-diisopropylphosphoramidite
• 英文别名: N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[4-(cyanomethyl)phenyl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
• 化学式: C₅₀H₅₈N₇O₈P
• 分子量: 916.026
• InChiKey: NQYLENQRANAGTR-YEFNKLFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  66
• 可旋转键数：
  20
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  171
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  N2-异丁酰-5'-O-(4,4'-二甲氧基三苯基)-2'-脱氧鸟苷 在 吡啶 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 N2-isobutyryl-5'-O-dimethoxytrityl-2'-deoxyguanosine-3'-O-(4-cyanomethylbenzyl)-N,N-diisopropylphosphoramidite
  参考文献：
  名称：

  Efficient Synthesis of Deoxyribonucleoside Phosphoramidites by Eliminating the Use of Additional Activator

  摘要：

  An efficient, safe and cost effective synthesis of deoxyribonucleoside phosphoramidites is described. The amine hydrochloride produced as a by-product during the synthesis of nucleoside phosphorbisamidite is used as an internal activator in the synthesis of phosphoramidites.

  DOI：

  10.1080/07328319908044849

文献信息

• Method of preparing phosphoramidites
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06335439B1

  公开（公告）日：2002-01-01

  Improved methods for preparation of phosphoramidite compounds are disclosed. The phosphoramidites are useful, for example, for the preparation of oligonucleotides by solid state oligonucleotide synthetic regimes.

  揭示了改进的磷酰胺酰胺化合物制备方法。这些磷酰胺酰胺化合物可用于固相寡核苷酸合成方案的制备，例如。
• Efficient Synthesis of Deoxyribonucleoside Phosphoramidites by Eliminating the Use of Additional Activator
  作者：Alessandra Eleuteri、Daniel C. Capaldi、Douglas L. Cole Vasulinga、T. Ravikumar

  DOI：10.1080/07328319908044849

  日期：1999.8

  An efficient, safe and cost effective synthesis of deoxyribonucleoside phosphoramidites is described. The amine hydrochloride produced as a by-product during the synthesis of nucleoside phosphorbisamidite is used as an internal activator in the synthesis of phosphoramidites.