4-fluorophenyl 4-bromobenzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 4-fluorophenyl 4-bromobenzoate
• 英文别名: 4-bromobenzoic acid 4-fluorophenyl ester；4-Bromo-benzoic acid 4-fluoro-phenyl ester；(4-fluorophenyl) 4-bromobenzoate
• 化学式: C₁₃H₈BrFO₂
• 分子量: 295.108
• InChiKey: PXOUBADUWAGFJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟苯酚 、 4-溴苯甲酰氯 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 4-fluorophenyl 4-bromobenzoate
  参考文献：
  名称：

  [EN] COMPOUNDS THAT ABROGATE DNA-DAMAGE-INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT THE ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS
  [FR] COMPOSES QUI SUPPRIMENT LE POINT DE CONTROLE G2 DU CYCLE CELLULAIRE INDUIT PAR L'ADN ENDOMMAGE ET/OU QUI ACCROIT L'ACTIVITE ANTI-CANCEREUSE DES TRAITEMENTS ENDOMMAGEANT L'ADN

  摘要：

  公开号：

  WO2003104181A3

文献信息

• NHC−Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids
  作者：João N. Rosa、R. Sudarshan Reddy、Nuno R. Candeias、Pedro M. S. D. Cal、Pedro M. P. Gois

  DOI：10.1021/ol100302e

  日期：2010.6.18

  NHC−iron complexes prepared in situ very efficiently afforded benzoates via the aerobic oxidative aromatic esterification of aldehydes with boronic acids. This method uses equimolar amounts of both the aldehyde and the boronic acid allowing the preparation of benzoates in yields up to 97%.

  原位制备的NHC-铁络合物通过醛与硼酸的好氧氧化芳族酯化反应，非常有效地提供了苯甲酸酯。该方法使用等摩尔量的醛和硼酸，使得制备苯甲酸酯的产率高达97％。
• Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments
  申请人：——

  公开号：US20040198727A1

  公开（公告）日：2004-10-07

  The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

  本发明提供了一种抑制哺乳动物细胞，包括人类细胞，特别是DNA损伤诱导的G2检查点的细胞周期G2检查点的组成物和方法。具体而言，本发明提供了一种通过废除细胞周期G2检查点来使细胞对DNA损伤剂敏感的组成物和方法。本发明的化合物用于治疗增生性疾病，如癌症。本发明提供了一种选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗敏感的组成物和方法。
• Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments
  申请人：Kawabe Takumi

  公开号：US20060122269A1

  公开（公告）日：2006-06-08

  The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

  该发明提供了一种抑制哺乳动物细胞，包括人类细胞中的细胞周期G2检查点，特别是DNA损伤诱导的G2检查点的组合物和方法。具体而言，该发明提供了通过废除细胞周期G2检查点来使细胞对DNA损伤剂敏感的组合物和方法。该发明的化合物可用于治疗增殖性疾病，如癌症。该发明提供的组合物和方法可选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗方法敏感。
• COMPOUNDS THAT ABROGATE DNA DAMAGE INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS
  申请人：KAWABE Takumi

  公开号：US20080227827A1

  公开（公告）日：2008-09-18

  The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

  本发明提供了一种抑制细胞周期G2检查点，特别是DNA损伤诱导的G2检查点，在哺乳动物细胞，包括人类细胞中的组合物和方法。具体而言，本发明提供了一种通过废除细胞周期G2检查点使细胞对DNA损伤剂敏感的组合物和方法。本发明的化合物用于治疗增殖性疾病，如癌症。本发明提供了一种选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗方法敏感的组合物和方法。
• Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments
  申请人：Canbas Co., Ltd.

  公开号：US07629364B2

  公开（公告）日：2009-12-08

  The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

  本发明提供了一种抑制哺乳动物细胞，包括人类细胞中细胞周期G2检查点，特别是DNA损伤诱导的G2检查点的组合物和方法。具体而言，本发明提供了一种通过废除细胞周期G2检查点来使细胞对DNA损伤剂敏感的组合物和方法。本发明的化合物用于治疗增殖性疾病，如癌症。本发明提供了一种用于选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗方法敏感的组合物和方法。