2S-(5-Benzyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-sulfonic acid dimethylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2S-(5-Benzyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-sulfonic acid dimethylamide
• 英文别名: (2S)-2-(5-benzyl-1,3,4-oxadiazol-2-yl)-N,N-dimethylpiperidine-1-sulfonamide
• 化学式: C₁₆H₂₂N₄O₃S
• 分子量: 350.442
• InChiKey: DDYIPSLYUWKRBM-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  87.9
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  C₁₄H₁₆ClN₃O₃S 、 二甲胺 在 3,5-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 以45%的产率得到2S-(5-Benzyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-sulfonic acid dimethylamide
  参考文献：
  名称：

  An efficient synthesis of sulfamides

  摘要：

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.106

文献信息

• Compounds, compositions, and methods for stimulating neuronal growth and elongation
  申请人：——

  公开号：US20020061881A1

  公开（公告）日：2002-05-23

  The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.

  本发明涉及用于刺激神经元细胞中神经元生长的方法、药物化合物和组合物，从而导致神经再生。这些方法、化合物和组合物抑制了与结合蛋白相关的旋转酶酶活性。
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION
  申请人：AGOURON PHARMACEUTICALS, INC.

  公开号：EP1237869A1

  公开（公告）日：2002-09-11
• US6544987B2
  申请人：——

  公开号：US6544987B2

  公开（公告）日：2003-04-08
• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES PERMETTANT DE STIMULER LA CROISSANCE ET L'ELONGATION NEURITIQUES
  申请人：AGOURON PHARMA

  公开号：WO2001040185A1

  公开（公告）日：2001-06-07

  The present invention relates to compounds of formula (I) wherein A, B, X, D are defined in claim 1, and pharmaceutical compositions containing them for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.
• An efficient synthesis of sulfamides
  作者：Chuangxing Guo、Liming Dong、Susan Kephart、Xinjun Hou

  DOI：10.1016/j.tetlet.2010.03.106

  日期：2010.5

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.