4,4',2'',4''-tetramethoxy-2,6-dimethyl-3'-(1-methylethyl)triphenylmethane

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4,4',2'',4''-tetramethoxy-2,6-dimethyl-3'-(1-methylethyl)triphenylmethane
• 英文别名: 2-[(2,4-Dimethoxyphenyl)-(4-methoxy-3-propan-2-ylphenyl)methyl]-5-methoxy-1,3-dimethylbenzene
• 化学式: C₂₈H₃₄O₄
• 分子量: 434.576
• InChiKey: NQIRBEUOFLFOHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间苯二甲醚 以90%的产率得到4,4',2'',4''-tetramethoxy-2,6-dimethyl-3'-(1-methylethyl)triphenylmethane
  参考文献：
  名称：

  THYROID HORMONE ANALOGUES AND METHODS FOR THEIR PREPARATION

  摘要：

  公开号：

  EP1089968B1

文献信息

• An efficient substitution reaction for the preparation of thyroid hormone analogues
  作者：Hikari A.I. Yoshihara、Grazia Chiellini、Timothy J. Mitchison、Thomas S. Scanlan

  DOI：10.1016/s0968-0896(98)00085-6

  日期：1998.8

  The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone

  有效的甲状腺激素激动剂GC-1的位阻碳取代是通过基于苄基羟基溶剂分解的反应进行的。发现该反应可与多种亲核试剂（包括醇，硫醇，烯丙基硅烷和富电子芳族化合物）以高收率进行，从而为合成新型甲状腺激素类似物提供了便利的途径。
• Thyroid hormone analogues and methods for their preparation
  申请人：The Regents of the University of California

  公开号：EP1598334A1

  公开（公告）日：2005-11-23

  Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.

  公开了甲状腺激素类似物。还公开了使用这些类似物的方法和含有这些类似物的药物组合物，以及制备这些类似物的新程序。
• EP1089968A4
  申请人：——

  公开号：EP1089968A4

  公开（公告）日：2002-08-21
• US6107517A
  申请人：——

  公开号：US6107517A

  公开（公告）日：2000-08-22
• [EN] THYROID HORMONE ANALOGUES AND METHODS FOR THEIR PREPARATION<br/>[FR] ANALOGUES DES HORMONES THYROIDIENNES ET METHODES DE PREPARATION ASSOCIEES
  申请人：UNIV CALIFORNIA

  公开号：WO2000000468A1

  公开（公告）日：2000-01-06

  Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.