1-cyclohexyloxy-3-methyl-3-phospholene 1-oxide | 3858-23-9

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦酸及其衍生物
• 英文名称: 1-cyclohexyloxy-3-methyl-3-phospholene 1-oxide
• 英文别名: 1-cyclohexoxy-3-methyl-3-phospholene oxide；1-cyclohexyloxy-3-methyl-2,5-dihydro-1H-phosphole 1-oxide；1-(Cyclohexyloxy)-3-methyl-3-phospholene 1-oxide；1-cyclohexyloxy-3-methyl-2,5-dihydro-1λ5-phosphole 1-oxide
• CAS: 3858-23-9
• 化学式: C₁₁H₁₉O₂P
• 分子量: 214.244
• InChiKey: AYMHKAGSVQHKOU-UHFFFAOYSA-N

物化性质

• 沸点：
  124-126 °C(Press: 0.02 Torr)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己醇 、 1-hydroxy-3-methyl-3-phospholene 1-oxide 在 1-丙基磷酸酐 作用下， 以 乙酸乙酯 为溶剂， 反应 2.17h， 以89%的产率得到1-cyclohexyloxy-3-methyl-3-phospholene 1-oxide
  参考文献：
  名称：

  Esterification of five-membered cyclic phosphinic acids under mild conditions using propylphosphonic anhydride (T3P®)

  摘要：

  1-Hydroxy-phospholene 1-oxides (1 and 3) and 1-hydroxy-phospholane oxides (5 and 7) undergo fast and efficient esterification with a series of alcohols, at room temperature, in the presence of 1.1 equiv of propylphosphonic anhydride (T3P (R)). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.082

文献信息

• Synthesis of Cyclic Phosphinates by Microwave-Assisted Ionic-Liquid-Promoted Alcoholysis
  作者：György Keglevich、Nikoletta Harsági、Nóra Zsuzsa Kiss、László Drahos

  DOI：10.1055/a-1504-8924

  日期：2022.9

  A series of 1-alkoxy-3-methyl- and 3,4-dimethyl-3-phospholene 1-oxides, as well as 1-alkoxy-3-methylphospholane 1-oxides were prepared in good yields by the microwave (MW)-assisted [bmim][PF6]-catalyzed transesterification of the corresponding methyl or ethyl esters. The alcoholyses studied represent another case, where MW irradiation has had a crucial role on the course of the reaction. The method

  通过微波 (MW) 以良好的收率制备了一系列 1-烷氧基-3-甲基-和 3,4-二甲基-3-磷烯 1-氧化物以及 1-烷氧基-3-甲基磷烯 1-氧化物-辅助 [bmim][PF6] 催化的相应甲酯或乙酯的酯交换。所研究的醇解代表了另一种情况，其中 MW 辐射在反应过程中起着至关重要的作用。所开发的方法是从相应的次膦酰氯和酸开始的其他酯化的替代可能性。
• Vizel,A.O. et al., Doklady Chemistry, 1965, vol. 160, p. 120 - 123
  作者：Vizel,A.O. et al.

  DOI：——

  日期：——
• Esterification of five-membered cyclic phosphinic acids under mild conditions using propylphosphonic anhydride (T3P®)
  作者：Erzsébet Jablonkai、Mátyás Milen、László Drahos、György Keglevich

  DOI：10.1016/j.tetlet.2013.08.082

  日期：2013.10

  1-Hydroxy-phospholene 1-oxides (1 and 3) and 1-hydroxy-phospholane oxides (5 and 7) undergo fast and efficient esterification with a series of alcohols, at room temperature, in the presence of 1.1 equiv of propylphosphonic anhydride (T3P (R)). (C) 2013 Elsevier Ltd. All rights reserved.