cis-4-hydroxy-1-(4-phenoxybenzyl)-5-trityloxymethylpyrrolidin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: cis-4-hydroxy-1-(4-phenoxybenzyl)-5-trityloxymethylpyrrolidin-2-one
• 英文别名: (4S,5S)-4-hydroxy-1-[(4-phenoxyphenyl)methyl]-5-(trityloxymethyl)pyrrolidin-2-one
• 化学式: C₃₇H₃₃NO₄
• 分子量: 555.673
• InChiKey: MFGOXEAJSJIRCO-PXLJZGITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cis-4-hydroxy-1-(4-phenoxybenzyl)-5-trityloxymethylpyrrolidin-2-one 、 甲基磺酰氯 在 三乙胺 作用下， 以 氯仿 、 乙酸乙酯 为溶剂， 以100%的产率得到cis-4-methanesulfonyloxy-1-(4-phenoxybenzyl)-5-trityloxymethylpyrrolidin-2-one
  参考文献：
  名称：

  Thiol compounds, their production and use

  摘要：

  通式（1）表示的化合物或其盐具有基质金属蛋白酶抑制活性，并且可用作药物，其中环A和环B分别表示可选择取代的同环或异环等；R1s相同或不同，每个代表氢，可选择取代的烃基，酰基等；X1表示键，可选择取代的二价脂肪烃基等；X2表示键，可选择取代的二价脂肪烃基，—O—等；Ys相同或不同，代表氢，可选择取代的烃基，氧代，等；m为0或1；n为1到3的整数；q1为1到2n+4的整数；q2为0到2n+3的整数，前提是q1+q2为2n+4。

  公开号：

  US06420415B1
• 作为产物：
  描述：

  cis-4-hydroxy-5-hydroxymethyl-1-(4-phenoxybenzyl)pyrrolidin-2-one 、 三苯基氯甲烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 氯仿 、 乙酸乙酯 为溶剂， 以79%的产率得到cis-4-hydroxy-1-(4-phenoxybenzyl)-5-trityloxymethylpyrrolidin-2-one
  参考文献：
  名称：

  Thiol compounds, their production and use

  摘要：

  通式（1）表示的化合物或其盐具有基质金属蛋白酶抑制活性，并且可用作药物，其中环A和环B分别表示可选择取代的同环或异环等；R1s相同或不同，每个代表氢，可选择取代的烃基，酰基等；X1表示键，可选择取代的二价脂肪烃基等；X2表示键，可选择取代的二价脂肪烃基，—O—等；Ys相同或不同，代表氢，可选择取代的烃基，氧代，等；m为0或1；n为1到3的整数；q1为1到2n+4的整数；q2为0到2n+3的整数，前提是q1+q2为2n+4。

  公开号：

  US06420415B1

文献信息

• NOVEL THIOL DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1132379A1

  公开（公告）日：2001-09-12

  The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each R1 may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR2, etc., X1 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group or -NR3-, etc, X2 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group, -NR4-, -O- or -S(O)p-(wherein p is 0, 1 or 2), each Y may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, a halogen atom, a carboxyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR5, an oxo group, a thioxo group, an optionally substituted imino group, a nitro group, a cyano group, etc., each m may be same or different and is 0 or 1, n is an integer of 1 to 3, q1 is an integer of 1 to 2n+4, q2 is an integer of 0 to 2n+3, and the sum of q1 and q2 is 2n+4 or a salt thereof.

  本发明提供了一种由式表示的化合物： 其中，环 A 和环 B 可以相同或不同，并且各自是任选取代的同环或杂环等，每个 R1 可以相同或不同，并且是氢原子、任选取代的烃基、酰基、任选取代的杂环基团或 SR2 等、X1 是键、任选取代的二价 C1-3 脂肪族烃基或-NR3-等，X2 是键、任选取代的二价 C1-3 脂肪族烃基、-NR4-、-O-或-S(O)p-（其中 p 为 0、1 或 2），每个 Y 可以相同或不同，并且是氢原子、任选取代的烃基、卤素原子、羧基、酰基、任选取代的羟基、任选取代的氨基、SR5、氧代基团、硫代基团、任选取代的亚氨基、硝基、氰基等。,每个 m 可以相同或不同，且为 0 或 1，n 为 1 至 3 的整数，q1 为 1 至 2n+4 的整数，q2 为 0 至 2n+3 的整数，且 q1 和 q2 之和为 2n+4 或其盐。
• Process for lining canals, ditches and pipes with a non-sagging polyurethane/geofabric composite
  申请人：——

  公开号：US20020172561A1

  公开（公告）日：2002-11-21

  A surface of a canal, ditch or pipe is lined with a polyurethane/geofabric composite. A non-sagging polyurethane composition is applied to the canal, ditch or pipe surface, a geofabric is contacted with that surface in a manner such that the geofabric becomes impregnated with the non-sagging polyurethane composition which cures to form a polyurethane/geofabric composite. The non-sagging polyurethane is a reaction product of a polyisocyanate, a high molecular weight polyhydroxyl compound and a compound having at least 2 amino groups. A low molecular weight diol or triol, filler and catalyst are optional components. These composites are particularly useful in lining cracked or broken concave or angled surfaces.

  运河、沟渠或管道的表面衬有聚氨酯/土工织物复合材料。在运河、沟渠或管道表面涂抹不下垂聚氨酯组合物，土工织物与运河、沟渠或管道表面接触，使土工织物浸渍在不下垂聚氨酯组合物中，聚氨酯组合物固化后形成聚氨酯/土工织物复合材料。不下垂聚氨酯是多异氰酸酯、高分子量多羟基化合物和至少有 2 个氨基的化合物的反应产物。低分子量的二元醇或三元醇、填料和催化剂是可选成分。这些复合材料尤其适用于衬垫开裂或破损的凹面或斜面。
• Polyurethane-forming composition with adjustable mix viscosity, geotextile composites prepared therefrom and a process for producing such composites
  申请人：——

  公开号：US20030032718A1

  公开（公告）日：2003-02-13

  A polyurethane-forming reaction mixture characterized by its ability to be adjusted with respect to its viscosity in response to changing temperature and humidity conditions is achieved with a mixture that includes a liquid polyisocyanate having an isocyanate group content of at least 10% by weight, an isocyanate-reactive component which includes at least one high molecular weight polyol, a urethane catalyst and from 0.2 to 5 parts by weight per 100 parts by weight of isocyanate reactive component of a viscosity adjusting component. The viscosity adjusting component is preferably a diamine, a polyamine and/or an amine-terminated polyol. This reaction mixture is particularly useful for producing polyurethane geotextile composite materials useful as liners for ditches and canals.

  一种聚氨酯成型反应混合物，其特点是能够根据温度和湿度条件的变化调节其粘度，该混合物包括异氰酸酯基含量至少为 10%（重量比）的液态多异氰酸酯、异氰酸酯反应组分（其中包括至少一种高分子量多元醇）、聚氨酯催化剂以及每 100 份异氰酸酯反应组分中 0.2 至 5 份（重量比）的粘度调节组分。粘度调节组分最好是二胺、多胺和/或胺封端多元醇。这种反应混合物特别适用于生产用作沟渠衬里的聚氨酯土工织物复合材料。
• Polyurethane/geotextile composite liner for canals and ditches based on liquefied monomeric MDI-derivatives
  申请人：——

  公开号：US20030206775A1

  公开（公告）日：2003-11-06

  An improved polyurethane/geotextile composite is prepared from a polyurethane forming composition in which a liquefied monomeric diphenylmethane diisocyanate (MDI) is used as the isocyanate component. Such composites may be used to line canals and/or ditches by applying the geotextile soaked with polyurethane forming composition to the surface to be lined before the polyurethane-forming reaction has been completed and allowing the polyurethane to cure in place. These composites are characterized by improved physical and mechanical properties and the ability to withstand dramatic changes in the temperature of the environment in which they are employed.

  一种改进的聚氨酯/土工织物复合材料是用一种聚氨酯成型组合物制备的，在这种组合物中，液化单体二苯基甲烷二异氰酸酯（MDI）被用作异氰酸酯组分。这种复合材料可用于衬砌运河和/或沟渠，方法是在聚氨酯成型反应完成之前，将浸透了聚氨酯成型组合物的土工织物涂抹到要衬砌的表面，并让聚氨酯就地固化。这些复合材料的特点是具有更好的物理和机械性能，能够承受使用环境温度的急剧变化。
• POLYURETHANE-FORMING COMPOSITION WITH ADJUSTABLE MIX VISCOSITY, GEOTEXTILE COMPOSITES PREPARED THEREFROM AND A PROCESS FOR PRODUCING SUCH COMPOSITES
  申请人：Bayer Corporation

  公开号：EP1373352A1

  公开（公告）日：2004-01-02