magnesium,1-methanidyl-4-methoxybenzene,bromide | 31179-52-9

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: magnesium,1-methanidyl-4-methoxybenzene,bromide
• 英文别名: p-anisylmagnesium bromide；4-methoxyphenylmethylmagnesium bromide；(4-methoxybenzyl)magnesium bromide；(4-methoxyphenyl)magnesium bromide；4-methoxybenzylmagnesium bromide；p-methoxybenzylmagnesium bromide；4-anisylmagnesium bromide
• CAS: 31179-52-9
• 化学式: C₈H₉BrMgO
• 分子量: 225.368
• InChiKey: MZFZJDUMJNWMMD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.21
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  magnesium,1-methanidyl-4-methoxybenzene,bromide 在 sodium hydroxide 、 四正丁基硫酸铵 作用下， 以 乙醚 、 二氯甲烷 、 苯 为溶剂， 反应 12.0h， 生成 2-[2-(4-甲氧基苯基)乙基]环氧乙烷
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents: substituted phenylalkanolamines. Effect of side-chain length on .beta.-blocking potency in vitro

  摘要：

  The synthesis of a group of potential beta-blockers bearing a new 5-ethoxysalicylamide substituent on nitrogen is described. These compounds were tested for beta-adrenergic blocking potency in vitro and compared with analogous compounds bearing a tert-butyl group on nitrogen. The new N-substituent increased the beta-blocking potency substantially. In a series of five homologous compounds of the type Ar(CH2)nCHOHCH2NHR (R = 5-ethoxysalicylamide; n = 0-4), two maxima of beta-blocking potency were found for n = 0 and 2. Moreover, the carbon isostere of the corresponding (aryloxy)propanolamine still proved to be a very potent beta-blocker. The ether oxygen in the side chain is therefore not an absolute requirement for activity. Structure-activity relationships are discussed.

  DOI：

  10.1021/jm00373a003
• 作为产物：
  描述：

  4-甲氧基溴苄 生成 magnesium,1-methanidyl-4-methoxybenzene,bromide
  参考文献：
  名称：

  MULLEN G. B.; GEORGIEV V. ST., HETEROCYCLES, 24,(1986) N 12, 3441-3446

  摘要：

  DOI：

文献信息

• [EN] IRON BISPHENOLATE COMPLEXES AND METHODS OF USE AND SYNTHESIS THEREOF<br/>[FR] COMPLEXES BISPHÉNOLATES DE FER ET LEURS PROCÉDÉS D'UTILISATION ET DE SYNTHÈSE
  申请人：UNIV PRINCE EDWARD ISLAND

  公开号：WO2013053046A1

  公开（公告）日：2013-04-18

  The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R1 and R2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

  本申请涉及铁双酚酸酯配合物及其使用和合成方法。这些铁配合物是从三齿或四齿配体的化学式I制备而成的：其中R1和R2如本文所定义。还提供了使用铁双酚酸酯配合物作为催化剂进行交叉偶联反应和控制自由基聚合的方法和过程。
• A Facile Synthesis of 4-Benzylpyridines by Regiospecific Addition of Substituted Benzylic Griganard Reagents to Pyridinium Salts
  作者：Min-Jen Shiao、Win-Long Chia

  DOI：10.1080/00397919108016762

  日期：1991.2

  Abstract Substituted 4-benzylpyridines are prepared by regiospecific γ-addition of substituted benzylic Grinard reagents to pyridinium salts in fairly good yeilds.

  摘要 取代的 4-苄基吡啶是通过取代苄基格氏试剂与吡啶盐的区域特异性 γ-加成反应制备的，收率相当好。
• Development of the Vinylogous Pictet–Spengler Cyclization and Total Synthesis of (±)‐Lundurine A
  作者：Aaron Nash、Xiangbing Qi、Pradip Maity、Kyle Owens、Uttam K. Tambar

  DOI：10.1002/anie.201803702

  日期：2018.6.4

  A novel vinylogous Pictet–Spengler cyclization has been developed for the generation of indole‐annulated medium‐sized rings. The method enables the synthesis of tetrahydroazocinoindoles with a fully substituted carbon center, a prevalent structural motif in many biologically active alkaloids. The strategy has been applied to the total synthesis of (±)‐lundurine A.

  一种新型的插烯 Pictet-Spengler 环化反应已被开发用于生成吲哚环状的中等尺寸的环。该方法能够合成具有完全取代的碳中心的四氢偶氮吲哚，这是许多生物活性生物碱中普遍存在的结构基序。该策略已应用于(±)-lundurine A的全合成。
• Aryloxyalkylamine NK-1/SSRI inhibitors
  申请人：Huang Yazhong

  公开号：US20060020019A1

  公开（公告）日：2006-01-26

  The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.

  本发明包括式I化合物，包括药物可接受的盐和溶剂化物，它们的药物组合物，以及它们用于治疗与速激肽或血清素或两者过量或不平衡相关的疾病。
• Total Syntheses of the 3<i>H</i>-Pyrrolo[2,3-<i>c</i>]quinolone-Containing Alkaloids Marinoquinolines A–F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway
  作者：Benoit Bolte、Christopher S. Bryan、Phillip P. Sharp、Soheil Sayyahi、Charly Rihouey、Amy Kendrick、Ping Lan、Martin G. Banwell、Colin J. Jackson、Nicholas J. Fraser、Anthony C. Willis、Jas S. Ward

  DOI：10.1021/acs.joc.9b02725

  日期：2020.1.17

  of the marinoquinoline family of natural products, together with the related marine alkaloid aplidiopsamine A (12), have been synthesized using various combinations of palladium-catalyzed Ullmann cross-coupling and reductive cyclization processes involving a C3-arylated pyrrole as the common intermediate. These natural products have been characterized by single-crystal X-ray analyses and evaluated as

  使用钯催化的Ullmann交叉偶联和涉及C3的还原环化过程的各种组合合成了代表天然产物马来喹啉家族主要成员的化合物1-6和11，以及相关的海洋生物碱Aplidiopsamine A（12）。 -芳基吡咯为常见中间体。这些天然产物已通过单晶X射线分析进行了表征，并被评估为乙酰胆碱酯酶（AChE）的抑制剂，同类物2被证明是活性最高的。