[Pt((15)N-en)Cl2] | 115160-63-9

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: [Pt((15)N-en)Cl2]
• 英文别名: {Pt((15)en)Cl2}；[PtCl₂(¹⁵N-ethane-1,2-diamine)]；¹⁵N-[Pt(ethylenediamine)Cl₂]；¹⁵N-[Pt(en)Cl₂]；[PtCl₂(¹⁵N-en)]；[Pt¹⁵N-enCl2]
• CAS: 115160-63-9
• 化学式: C₂H₈Cl₂N₂Pt
• 分子量: 328.072
• InChiKey: LMABILRJNNFCPG-SFXOSDSGSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pt((15)N-en)Cl2] 在 H₂O 作用下， 生成
  参考文献：
  名称：

  Berners-Price, Susan J.; Frey, Urban; Ranford, John D., Journal of the American Chemical Society, 1993, vol. 115, # 19, p. 8649 - 8659

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 ¹⁵N-1,2-ethanediamine dihydrochloride 生成 [Pt((15)N-en)Cl2]
  参考文献：
  名称：

  Austin, Elliot J. W.; Barrie, Patrick J.; Clark, Robin J. H., Inorganic Chemistry, 1992, vol. 31, # 21, p. 4281 - 4285

  摘要：

  DOI：

文献信息

• Diaminehalogenoplatinum(II) complex reactions with DMSO
  作者：Jens Josephsen

  DOI：10.1016/j.ica.2018.03.039

  日期：2018.6

  en-series. For all six [Pt(N-N)X 2 ] complexes the solvolysis stopped at the coordination of one DMSO and the six new [Pt(N-N)DMSOX]X were isolated and characterised. Further the [PtenDMSOCl] + was isolated as its nitrate and perchlorate. DMSO exchange reactions (in DMSO) of [PtenDMSOX] + were found to be slightly slower than the solvolysis reactions, iodide again giving rise to the most labile system. Ion

  摘要合成了铂（II）配合物[Pt（NN）X 2]（X = Cl，Br和I；（NN）= 1,2-乙二胺（en）和1,3-丙二胺（tn）） ; 通过改变NMR光谱信号的积分跟踪他们与DMSO在DMSO中取代卤化物的反应。发现[PtenCl 2]的速率常数在300K下为1.0×10 -4 s -1，并且根据在不同温度下的动力学运行，在这种情况下，活化能估计为82kJ×mol -1。速率常数取决于卤化物的大小，发现[PtenI 2]比其二氯类似物大40倍。在tn系列中，反应比在en-系列中要快一些。对于所有六种[Pt（NN）X 2]配合物，溶剂分解均在一种DMSO的配合下停止，并分离出六种新的[Pt（NN）DMSOX] X并进行了表征。进一步分离出[PtenDMSOC1] +的硝酸盐和高氯酸盐。发现[PtenDMSOX] +的DMSO交换反应（在DMSO中）比溶剂分解反应稍慢，碘化物再次导致最不稳
• Stabilization of monofunctional platinum–nucleotide adducts: reactions of N-acetyl-<scp>L</scp>-methionine complexes with guanosine 5′-monophosphate and guanylyl(3′–5′)guanosine
  作者：Kevin J. Barnham、Zijian Guo、Peter J. Sadler

  DOI：10.1039/dt9960002867

  日期：——

  [Pt(en)Cl2], whereas 2 was stable in water. The reaction of 1n with guanosine 5′-monophosphate (5′-GMP) gave a stable mixed-ligand complex [Pt([15N]en)MeCO-Met(1–)-S}(5′-GMP-N7)]+, and the reaction with guanylyl(3′-5′)guanosine (GpG) gave two different monofunctional adducts [Pt([15N]en)MeCO-Met(1–)-S}(GpG-N7)]+, due to platination of either 3′- or 5′-G, with a preferential formation of one over the other

  [Pt（en）MeCO-Met- S）Cl] NO 3 1，[Pt（en）（MeCO-Met- S）2 ] [NO 3 ] 2 2（en =乙烷-1,2-二胺，已制备MeCO-Met = N-乙酰基-L-甲硫氨酸及其15 N类似物（1n和2n），并通过1 H，13 C和二维[ 1 H，15 N]光谱进行了表征。复合物1（在310 K下半衰期为3.9小时）的水解速度比[Pt（en）Cl 2 ]慢，而2在水中稳定。1n与鸟苷5'-单磷酸酯（5'-GMP）的反应产生了稳定的混合配体络合物[Pt（[ 15 N] en）MeCO-Met（1 –）- S }（5'-GMP- N 7）] +，与鸟苷基（3'-5'）鸟苷（GpG）的反应产生了两个不同的单官能团加合物[Pt（[ 15 N] en）MeCO-Met（1 –）- S }（GpG- N 7）] +，由于3'-G或5'-G的电镀反应，优先形成一
• Cysteine-Directed Bioconjugation of a Platinum(II)–Acridine Anticancer Agent
  作者：Xiyuan Yao、Christopher M. Tracy、Ulrich Bierbach

  DOI：10.1021/acs.inorgchem.8b02717

  日期：2019.1.7

  Classical maleimide Michael addition chemistry in conjunction with copper-free click chemistry was investigated as a synthetic strategy to attach cytotoxic platinum–acridine hybrid agents to carrier proteins. The structural integrity and selectivity of the model payloads, which were validated in human serum albumin (HSA) using mass spectrometric analysis and heteronuclear 2D 1H–15N HSQC NMR experiments

  研究了经典的马来酰亚胺迈克尔加成化学与无铜点击化学的结合，以此作为一种将细胞毒性的铂hybrid啶杂化剂与载体蛋白结合的合成策略。模型有效负载的结构完整性和选择性已通过质谱分析和异核2D 1 H- 15 N HSQC NMR实验在人血清白蛋白（HSA）中得到验证，可用于靶向递送高细胞毒性铂a啶和其他非经典的含铂抗癌药。
• On the origin of the hyperfine structure in the photoinduced EPR spectrum of [Pt(en)2]Pt(en)2Cl2](ClO4)4
  作者：C.A. Arrington、C.J. Unkefer、R.J. Donohoe、S.C. Huckett、S. Kurita、B.I. Swanson

  DOI：10.1016/0038-1098(92)90806-k

  日期：1992.12

  The nitrogen isotope dependence of the EPR spectrum of the photoinduced paramagnetic defects in the halide-bridged platinum linear chain complex [Pt(en)2][Pt(en)2Cl2](ClO4)4 (en = ethylenediamine) has been studied in order to clarify the origin of the 16G hyperfine structure which is superimposed on the 180 G hyperfine pattern due to two equivalent Pt nuclei. An earlier study attributed the 16 G pattern to the equatorial chelating nitrogens: however, we find that the EPR spectrum obtained for the N-15-substituted species is identical to that obtained for the normal isotopic species, demonstrating that these off-axis nitrogens are not the origin of this splitting. On the basis of this observation and simulations of the EPR spectrum, we attribute the 16G hyperfine pattern to coupling with three or more chlorine nuclei on the chain axis. The origin of the photoinduced paramagnetic defect in PtCl, whether polaronic or neutral kink soliton, is discussed in view of this new data. These results clearly demonstrate the importance of including halide orbitals in many-body models of the quasi-one-dimensional MX chain solids.
• Nucleotide Cross-Linking Induced by Photoreactions of Platinum(IV)–Azide Complexes
  作者：Philippe Müller、Björn Schröder、John A. Parkinson、Nicole A. Kratochwil、Robert A. Coxall、Andrew Parkin、Simon Parsons、Peter J. Sadler

  DOI：10.1002/anie.200390110

  日期：2003.1.20