3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol | 112510-75-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol
• 英文别名: 3-[(4-methoxytrityl)amino]propan-1-ol；3-(4-monomethoxytrityl)amino-1-propanol；3-[((4-methoxyphenyl)diphenylmethyl)amino]propan-1-ol；N-Monomethoxytrityl Aminopropanol；3-[[(4-Methoxyphenyl)-diphenylmethyl]amino]propan-1-ol
• CAS: 112510-75-5
• 化学式: C₂₃H₂₅NO₂
• 分子量: 347.457
• InChiKey: YLDIFIJXVOGQMU-UHFFFAOYSA-N

物化性质

• 沸点：
  503.1±50.0 °C(Predicted)
• 密度：
  1.111±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol 以 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 为溶剂， 生成 (2-cyanoethoxy)<(diisopropyl)amino>(3-<(4-methoxytrityl)amino>propoxy)phosphine
  参考文献：
  名称：

  Antiviral liposome having coupled target-binding moiety and hydrolytic

  摘要：

  制备了含有两种或更多不同效应分子的复合物，这些分子通过连接组分连接在一起。至少一种效应分子可以结合到目标分子，而其他效应分子中至少一种具有治疗特性。连接组分可以是脂质体、蛋白质和有机聚合物，包括树状聚合物，可以具有足够的长度和/或柔性，以允许治疗效应分子与结合分子同时与目标分子相互作用。通过将能够消化病毒成分和具有针对HIV-1、流感病毒和肝炎病毒等病毒特异性的多肽、糖蛋白或糖蛋白片段的目标结合基团耦合到脂质体外表面，制备了一种抗病毒脂质体。水解酶可以是糖苷酶、磷脂酶、脂肪酶、胆固醇酯酶、核酸酶或蛋白酶。第二种水解酶和目标结合基团也可能存在，并且白蛋白可以耦合到脂质体表面。在脂质体内部可能含有能够消化病毒成分的内部水解酶。

  公开号：

  US05718915A1
• 作为产物：
  描述：

  N-<(4-methoxyphenyl)diphenylmethyl>-β-alanine benzylester 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以99%的产率得到3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol
  参考文献：
  名称：

  邻菲咯啉-钌（II）络合物作为寡核苷酸的非放射性标记，可以通过时间分辨荧光技术进行测量

  摘要：

  描述了作为非放射性标记分子的红菲咯啉-钌（II）复合物与合成5'-NH 2修饰的寡核苷酸的特异性连接。通过光脉冲激发后，这些标记物的荧光可以通过具有高灵敏度的时间分辨模式进行测量。由于Ru复合物与DNA的偶联，没有猝灭发生。Ru-复合物标记的寡核苷酸仍与互补的DNA序列特异性杂交，并且在杂交过程中未观察到淬灭。

  DOI：

  10.1002/hlca.19880710826

文献信息

• Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay
  作者：Gene M Dubowchik、Jonathan L Ditta、John J Herbst、Sagarika Bollini、Alexander Vinitsky

  DOI：10.1016/s0960-894x(00)00045-7

  日期：2000.3

  Several fluoresceinated FKBP12 ligands have been prepared for a high-throughput fluorescence polarization assay. K(i)s for FKBP12 rotamase inhibition by these ligands range from 1.3 microM to 32 nM, and their design is based on X-ray crystal structures of FKBP12 complexed with known immunophilin ligands.

  已经准备好几种荧光素化的FKBP12配体用于高通量荧光偏振测定。这些配体抑制FKBP12旋转酶的K（i）为1.3 microM至32 nM，其设计基于与已知亲免蛋白配体复合的FKBP12的X射线晶体结构。
• Fluorescent quenching detection reagents and methods
  申请人：Epoch Biosciences, Inc.

  公开号：US06699975B2

  公开（公告）日：2004-03-02

  Oligonucleotide-fluorophore-quencher conjugates wherein the fluorophore moiety has emission wavelengths in the range of about 300 to about 800 nm, and or where the quencher includes a substituted 4-(phenyldiazenyl)phenylamine structure provide improved signal to noise ratios and other advantageous characteristics in hybridization and related assays. The oligonucleotide-fluorophore-quencher conjugates can be synthesized by utilizing novel phosphoramidite reagents that incorporate the quencher moiety based on the substituted 4-(phenyidiazenyl)phenylamine structure, and or novel phosphoramidite reagents that incorporate a fluorophore moiety based on the substituted coumarin, substituted 7-hydroxy-3H-phenoxazin-3-one, or substituted 5,10-dihydro-10-[phenyl]pyrido[2,3-d;6,5-d′]dipyrimidine-2,4,6,8-(1H,3H,7H,9H,10H)-tetrone structure. Oligonucleotide-fluorophore-quencher-minor groove binder conjugates including a pyrrolo[4,5-e]indolin-7-yl}carbonyl) pyrrolo[4,5-e]indolin-7-yl]carbonyl}pyrrolo[4,5-e]indoline-7-carboxylate (DPI3) moiety as the minor groove binder and the substituted 4-(phenyldiazenyl)phenylamine moiety as the quencher, were synthesized and have substantially improved hybridization and signal to noise ratio properties.

  寡核苷酸-荧光素-猝灭剂共轭物，其中荧光素部分的发射波长在大约300到800纳米范围内，或者猝灭剂包括取代的4-(苯基重氮基)苯胺结构，在杂交和相关测定中提供了改善的信噪比和其他有利特性。这些寡核苷酸-荧光素-猝灭剂共轭物可以通过利用基于取代的4-(苯基重氮基)苯胺结构的新型磷酸酰胺试剂合成，或者利用基于取代香豆素、取代7-羟基-3H-苯并噁唑-3-酮或取代5,10-二氢-10-[苯基]吡啶[2,3-d;6,5-d']二嘧啶-2,4,6,8-(1H,3H,7H,9H,10H)-四酮结构的新型磷酸酰胺试剂合成。包括吡咯并[4,5-e]吲哚-7-基)吡咯并[4,5-e]吲哚-7-基)吡咯并[4,5-e]吲哚-7-羧酸酯(DPI3)部分作为次生沟结合剂和取代的4-(苯基重氮基)苯胺部分作为猝灭剂的寡核苷酸-荧光素-猝灭剂-次生沟结合剂共轭物已经合成，并具有显着改善的杂交和信噪比特性。
• Method and device for improved restriction fragment length polymorphism analysis
  申请人：NATIVE PLANTS INCORPORATED

  公开号：EP0317239A2

  公开（公告）日：1989-05-24

  Described and claimed are a method and device useful for the rapid detection and analysis of restriction fragment length probe hybridization patterns using fluorescing labels and light emission detection technology.

  描述和权利要求是一种利用荧光标签和光发射检测技术快速检测和分析限制性片段长度探针杂交模式的方法和装置。
• Novel amino linkers enabling efficient labeling and convenient purification of amino-modified oligonucleotides
  作者：Yasuo Komatsu、Naoshi Kojima、Maiko Sugino、Akiko Mikami、Ken Nonaka、Yumi Fujinawa、Takashi Sugimoto、Kousuke Sato、Kenichi Matsubara、Eiko Ohtsuka

  DOI：10.1016/j.bmc.2007.10.011

  日期：2008.1

  We developed new amino linker reagents for an oligonucleotide (ONT) terminus. These reagents consist of an aminoethyl carbamate main linkage and a side-chain residue, which was a naphthylmethoxymethyl, methoxymethyl, or methyl group or a hydrogen atom. The primary amine was protected with a monomethoxytrityl (MMT) group. The chemical properties of ONTs containing these amino-modifications were investigated. The MMT group of these amino-modifications could be quite rapidly removed from the amine under very mild acidic conditions, which are not strong enough for the deprotection of a conventional aliphatic amine. This significant feature enabled the amino-modified ONTs to be conveniently purified with a reverse phase column. Furthermore, the amino-modifications efficiently reacted to active esters, as compared with other amino-modifications. We also found that the pK(a), values of the amino-modifications were lower than that of the aliphatic amine. All of the experimental results showed that these chemical properties are closely related to their structures. We report here the chemical properties and the availability of the new amino linker reagents. (C) 2007 Elsevier Ltd. All rights reserved.
• 5‘-Tethered Stilbene Derivatives as Fidelity- and Affinity-Enhancing Modulators of DNA Duplex Stability
  作者：Zeynep Dogan、Ralph Paulini、Jan A. Rojas Stütz、Sukunath Narayanan、Clemens Richert

  DOI：10.1021/ja0394434

  日期：2004.4.1

  A series of 5'-linked stilbene-DNA conjugates with different substituents in the distal aromatic ring of the stilbene was prepared, and the effect of the modifications on duplex stability was determined via UV-melting curves. A trimethoxystilbene derivative as a 5'-substituent increases duplex melting points by up to 12.2 degrees C per modification. With this alkoxystilbene substituent, terminal mismatches in DNA duplexes lower the melting point by up to 23.4 degrees C over the perfectly matched control, whereas terminal mismatches in unmodified DNA cause melting point depressions of no more than 6.1 degrees C. An aminomethylstilbene substituent linked to an oligopyrrolamide minor groove binder increases the melting point of an all-A/T decamer by up to 32.7 degrees C, thus shifting the melting point into a range typical for duplexes with statistical G/C-content. An affinity- and selectivity-enhancing effect was also observed when the trimethoxystilbene cap was employed on a small DNA microarray. The phosphoramidite of the trimethoxystilbene can be readily employed in automatic DNA synthesis, facilitating the generation of DNA chips with improved fidelity.