(4-iodophenyl)diphenylmethanol | 861097-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (4-iodophenyl)diphenylmethanol
• 英文别名: 1-(4-iodophenyl)-1,1-diphenylmethanol；(4-Jod-phenyl)-diphenyl-methanol；Hydroxy-diphenyl-(4-jod-phenyl)-methan；(4-Iodophenyl)-diphenylmethanol
• CAS: 861097-32-7
• 化学式: C₁₉H₁₅IO
• 分子量: 386.232
• InChiKey: OPDKIWCOXXPYNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-iodophenyl)diphenylmethanol 在 银 、 苯 作用下， 生成 1,2-bis-(4-iodo-phenyl)-1,1,2,2-tetraphenyl-ethane
  参考文献：
  名称：

  Organizational Buying and Advertising Agency-Client Relationships in China

  摘要：

  The 1980s and 1990s have seen the development of an interesting, diverse, and relevant body of literature on the advertising agency-client relationship. In recent times, an area of focus has been the application of organizational buying behavior principles to companies that are purchasing advertising services from advertising agencies. However, little is known about the application of such theories in the context of a developing country. After examining the literature relating to China's advertising industry and the application of organizational buying behavior principles in the advertising industry, this article reports on a survey of 200 firms in Shanghai. The results unexpectedly show that advertising agency power in the campaign development process is not related to the nature of the advertising task (new task, modified rebuy, straight rebuy) at hand. In addition, bottom-up processes give agencies the weakest pourer, and the client buying process is dominated by marketers, the salesforce, and public relations, with top managers the primary deciders.

  DOI：

  10.1080/00913367.2001.10673638
• 作为产物：
  描述：

  phenylmagnesium bromide 、 alkaline earth salt of/the/ methylsulfuric acid 在 苯 作用下， 生成 (4-iodophenyl)diphenylmethanol
  参考文献：
  名称：

  Organizational Buying and Advertising Agency-Client Relationships in China

  摘要：

  The 1980s and 1990s have seen the development of an interesting, diverse, and relevant body of literature on the advertising agency-client relationship. In recent times, an area of focus has been the application of organizational buying behavior principles to companies that are purchasing advertising services from advertising agencies. However, little is known about the application of such theories in the context of a developing country. After examining the literature relating to China's advertising industry and the application of organizational buying behavior principles in the advertising industry, this article reports on a survey of 200 firms in Shanghai. The results unexpectedly show that advertising agency power in the campaign development process is not related to the nature of the advertising task (new task, modified rebuy, straight rebuy) at hand. In addition, bottom-up processes give agencies the weakest pourer, and the client buying process is dominated by marketers, the salesforce, and public relations, with top managers the primary deciders.

  DOI：

  10.1080/00913367.2001.10673638

文献信息

• Molybdenum-Catalyzed Cross-Coupling of Benzyl Alcohols: Direct C–OH Bond Transformation via [2 + 2]-Type Addition and Elimination
  作者：Pan Zhou、Yuqiang Li、Tao XU

  DOI：10.1021/acs.orglett.2c01537

  日期：2022.6.17

  Traditional cross-couplings catalyzed by transition metal catalysts generally rely on the classic oxidative addition–transmetalation–reductive elimination process, which requires low-valent precious metals and an inert atmosphere and which initiates from carbon–alide or pesudo carbon–halide bonds. Herein, an unprecedented molybdenum–oxo-complex-catalyzed intermolecular cross-coupling of benzyl alcohols

  由过渡金属催化剂催化的传统交叉偶联通常依赖于经典的氧化加成-金属转移-还原消除过程，该过程需要低价贵金属和惰性气氛，并从碳-卤化物或拟碳-卤化物键引发。在此，报道了前所未有的钼-氧络合物催化苯甲醇的分子间交叉偶联。包括伯、仲和叔底物在内的各种醇可以在这些条件下有效地进行。对低价过渡金属敏感的几个官能团，如芳基卤化物，可以很好地耐受。机理研究和DFT计算表明分子内协同环化参与了反向[2 + 2]型消除过程。
• Aryl derivatives
  申请人：ZENECA LIMITED

  公开号：EP0488602A1

  公开（公告）日：1992-06-03

  The invention concerns an aryl derivative of the formula I, wherein Ar¹ is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X¹ is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X¹ is a group of the formula         -X⁴-CR₂- or -CR₂-X⁴- wherein X⁴ is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl; each of Ar² and Ar³ is optionally substituted phenylene; X² is oxy, thio, sulphinyl or sulphonyl; R¹ is (1-4C)alkyl; and R² and R³ together form a group of the formula -A¹-X³-A²- which together with the carbon atom to which A¹ and A² are attached define a ring having 5 to 7 ring atoms, wherein each of A¹ and A² is (1-3C)alkylene and X³ is oxy, thio, sulphinyl or sulphonyl; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease.

  本发明涉及一种式 I 的芳基衍生物、 其中 Ar¹ 是任选取代的苯基、萘基或杂环分子，X¹ 是氧、硫、亚硫酰基、磺酰基、二氟亚甲基、亚氨基、(1-4C)烷基亚氨基或任选取代的(1-4C)亚烷基，或 X¹ 是式中的基团 -X⁴-CR₂-或-CR₂-X⁴- 其中 X⁴ 是氧、硫、亚硫酰、磺酰或羰基，每个 R 是氢、甲基或乙基； Ar² 和 Ar³ 各为任选取代的亚苯基； X² 是氧基、硫代、亚砜基或磺酰基； R¹ 是 (1-4C) 烷基；以及 R² 和 R³ 共同形成一个式 -A¹-X³-A²- 的基团，该基团与 A¹ 和 A² 所连接的碳原子共同定义了一个具有 5 至 7 个环原子的环，其中 A¹ 和 A² 均为 (1-3C)亚烷基，X³ 为氧基、硫代、亚砜基或磺酰基； 这些化合物是 5-脂氧合酶的抑制剂，可用于治疗炎症或过敏性疾病。
• Structure−Activity Relationship and Multidrug Resistance Study of New <i>S</i>-trityl-<scp>l</scp>-Cysteine Derivatives As Inhibitors of Eg5
  作者：Hung Yi Kristal Kaan、Johanna Weiss、Dominik Menger、Venkatasubramanian Ulaganathan、Katarzyna Tkocz、Christian Laggner、Florence Popowycz、Benoît Joseph、Frank Kozielski

  DOI：10.1021/jm100991m

  日期：2011.3.24

  The mitotic spindle is a validated target for cancer chemotherapy. Drugs such as taxanes and vinca alkaloids specifically target microtubules and cause the mitotic spindle to collapse. However, toxicity and resistance are problems associated with these drugs. Thus, alternative approaches to inhibiting the mitotic spindle are being pursued. These include targeting Eg5, a human kinesin involved in the formation of the bipolar spindle. We previously identified S-trityl-L-cysteine (STLC) as a potent allosteric inhibitor of Eg5. Here, we report the synthesis of a new series of STLC-like compounds with in vitro inhibition in the low nanomolar range. We also performed a multidrug resistance study in cell lines overexpressing P-glycoprotein and showed that some of these inhibitors may have the potential to overcome susceptibility to this efflux pump. Finally, we performed molecular docking of the compounds and determined the structures of two Eg5-inhibitor complexes to explain the structure-activity relationship of these compounds.
• Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives
  作者：Daniel B. Nichols、Guy Fournet、K.R. Gurukumar、Amartya Basu、Jin-Ching Lee、Naoya Sakamoto、Frank Kozielski、Ira Musmuca、Benoît Joseph、Rino Ragno、Neerja Kaushik-Basu

  DOI：10.1016/j.ejmech.2012.01.010

  日期：2012.3

  Structure-based studies led to the identification of a constrained derivative of S-trityl-c-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for their activity against HCV NS5B. Three STLC derivatives, 9, F-3070, and F-3065, were identified as modest HCV NS5B inhibitors with IC50 values between 22.3 and 39.7 mu M. F-3070 and F-3065 displayed potent inhibition of intracellular NS5B activity in the BHK-NS5B-FRLuc reporter and also inhibited HCV RNA replication in the Huh7/Rep-Feo1b reporter system. Binding mode investigations suggested that the STLC scaffold can be used to develop new NS5B inhibitors by further chemical modification at one of the trityl phenyl group. (C) 2012 Elsevier Masson SAS. All rights reserved.
• US5225438A
  申请人：——

  公开号：US5225438A

  公开（公告）日：1993-07-06