4-methoxy-2-(pyridin-2-yl)phenyl benzoate | 1450914-80-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 4-methoxy-2-(pyridin-2-yl)phenyl benzoate
• 英文别名: 2-[(2-benzoyloxy-5-methoxy)phenyl]pyridine；(4-Methoxy-2-pyridin-2-ylphenyl) benzoate；(4-methoxy-2-pyridin-2-ylphenyl) benzoate
• CAS: 1450914-80-3
• 化学式: C₁₉H₁₅NO₃
• 分子量: 305.333
• InChiKey: QCEZFULFRKUWMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  碘苯二乙酸 在 palladium diacetate 作用下， 以 甲醇 、 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 8.5h， 生成 4-methoxy-2-(pyridin-2-yl)phenyl benzoate
  参考文献：
  名称：

  Palladium catalyzed ortho-C–H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates

  摘要：

  A palladium-catalyzed ortho-C-H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates has been developed. The reaction employed the stable and easily accessible hypervalent iodine reagents as both benzoxylate source and oxidant which made the protocol simple and facile. It showed high regioselectivity and good functional group tolerance, and gave the mono-benzoxylation products in moderate to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.09.097

文献信息

• Palladium(II)-Catalyzed othro-C–H-Benzoxylation of 2-Arylpyridines by Oxidative Coupling with Aryl Acylperoxides
  作者：Wing-Nga Sit、Chun-Wo Chan、Wing-Yiu Yu

  DOI：10.3390/molecules18044403

  日期：——

  A palladium(II)-catalyzed ortho-benzoxylation of 2-arylpyridines with aryl acylperoxides was developed. With pyridyl as directing group, the benzoxylation reaction exhibits remarkable regioselectivity and excellent functional group tolerance, providing the products in up to 87% yield.

  开发了一种钯(II)催化的2-芳基吡啶与芳基过氧化酮的邻位苯氧基化反应。以吡啶基作为指导基团，该苯氧基化反应表现出显著的区域选择性和优异的功能团耐受性，产物的收率高达87%。
• Palladium catalyzed ortho-C–H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates
  作者：Qian Zhang、Ying Wang、Tingting Yang、Li Li、Dong Li

  DOI：10.1016/j.tetlet.2015.09.097

  日期：2015.10

  A palladium-catalyzed ortho-C-H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates has been developed. The reaction employed the stable and easily accessible hypervalent iodine reagents as both benzoxylate source and oxidant which made the protocol simple and facile. It showed high regioselectivity and good functional group tolerance, and gave the mono-benzoxylation products in moderate to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.