N-环庚基-4-哌啶甲酰胺 | 429632-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-环庚基-4-哌啶甲酰胺
• 英文名称: piperidine-4-carboxylic acid cycloheptylamide
• 英文别名: N-cycloheptylpiperidine-4-carboxamide
• CAS: 429632-06-4
• 化学式: C₁₃H₂₄N₂O
• mdl: MFCD02922358
• 分子量: 224.346
• InChiKey: XKUDHOSLXFVHIT-UHFFFAOYSA-N

物化性质

• 沸点：
  413.4±34.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.923
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲基苯甲醛 、 N-环庚基-4-哌啶甲酰胺 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以82%的产率得到N-cycloheptyl-1-[(2,4,6-trimethylphenyl)methyl]piperidine-4-carboxamide
  参考文献：
  名称：

  Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase

  摘要：

  Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2011.10.074
• 作为产物：
  描述：

  Tert-butyl 4-(cycloheptylcarbamoyl)piperidine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以89%的产率得到N-环庚基-4-哌啶甲酰胺
  参考文献：
  名称：

  Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase

  摘要：

  Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2011.10.074

文献信息

• [EN] LOW MOLECULAR WEIGHT 2,5-DISUBSTITUTED THIOPHENE DERIVATIVES AND USE THEREOF IN THERAPY<br/>[FR] DÉRIVÉS DE THIOPHÈNE 2,5-DISUBSTITUÉS DE FAIBLE POIDS MOLÉCULAIRE ET LEUR UTILISATION EN THÉRAPIE
  申请人：NOVASAID AB

  公开号：WO2009098282A1

  公开（公告）日：2009-08-13

  A compound of formula (I). The compound is useful for the treatment of disorders such as pain, fever, inflammation and cancer. A method for preparing the compound.

  一种化合物的化学式（I）。该化合物可用于治疗疼痛、发热、炎症和癌症等疾病。一种制备该化合物的方法。
• NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
  申请人：Vago Istvan

  公开号：US20100087423A1

  公开（公告）日：2010-04-08

  The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R 1 -R 5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及新的苯磺酰苯酰胺衍生物，其化学式为(I)，其中R1-R5和Z如权利要求中所定义，以及其光学对映体或外消旋体和/或盐和/或水合物和/或溶剂合物，它们是缓激肽B1选择性拮抗剂，用于制备这些化合物的过程，包含它们的药理学组合物以及在治疗或预防疼痛和炎症症状中的应用。
• US8481527B2
  申请人：——

  公开号：US8481527B2

  公开（公告）日：2013-07-09