Ethyl 2-hydroxyethyl selenide | 115423-28-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Ethyl 2-hydroxyethyl selenide
• 英文别名: Ethanol, 2-(ethylseleno)-；2-ethylselanylethanol
• CAS: 115423-28-4
• 化学式: C₄H₁₀OSe
• 分子量: 153.083
• InChiKey: KJCOYZSZINYEFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.54
• 重原子数：
  6
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,2-bis(2-hydroxyethyl)diselenide 、 碘乙烷 在 sodium hydroxide 、 钾硼氢 作用下， 以 乙醚 、 水 为溶剂， 反应 8.0h， 生成 Ethyl 2-hydroxyethyl selenide
  参考文献：
  名称：

  One-Pot Two-Step Approach to Selenides. Phase-Transfer Catalyzed Synthesis of ω-Hydroxyalkyl Selenides

  摘要：

  omega-hydroxyalkyl selenides were synthesized in good yields under phase-transfer conditions which involved hadrazine reduction on selenium powder and then alkylation with omega-haloalkyl alcohols in the presence of TBAB, reduction the resulting diselenides with KBH4 followed by treatment with alkyl halides.

  DOI：

  10.1080/00397910008087348

文献信息

• A Facile Synthesis of 2- and 3-Hydroxyalkylseleno Compounds
  作者：Sang-Ihn Kang、Colin Paul Spears

  DOI：10.1055/s-1988-27490

  日期：——

  2-Hydroxyethylseleno and 3-hydroxypropylseleno compounds (selenides 6-9) have been prepared in good yields employing 2-hydroxyethyl and 3-hydroxypropyl selenocyanates (4 and 5). Several types of electrophilic substrates that reacted with the selenolate anions generated from 4 and 5 in situ in the presence of sodium borohydride included alkyl, benzylic, activated aromatic, benzoyl, and picolinyl halides.

  利用 2-羟乙基和 3-羟丙基硒氰酸酯（4 和 5）制备了 2-羟乙基硒酸盐和 3-羟丙基硒酸盐化合物（硒化物 6-9），收率很高。在硼氢化钠存在下，与 4 和 5 原位生成的硒酸根阴离子发生反应的亲电基质包括烷基、苄基、活化芳基、苯甲酰基和吡啶基卤化物。
• One-Pot Two-Step Approach to Selenides. Phase-Transfer Catalyzed Synthesis of ω-Hydroxyalkyl Selenides
  作者：Xubo Hu、Zhenjiao Tian、Yuanyin Chen、Xueran Lu

  DOI：10.1080/00397910008087348

  日期：2000.2

  omega-hydroxyalkyl selenides were synthesized in good yields under phase-transfer conditions which involved hadrazine reduction on selenium powder and then alkylation with omega-haloalkyl alcohols in the presence of TBAB, reduction the resulting diselenides with KBH4 followed by treatment with alkyl halides.