[1-[(2R,3S,4R,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylpropan-2-yl]oxy-(2-hydroxybutan-2-yl)phosphinic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: [1-[(2R,3S,4R,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylpropan-2-yl]oxy-(2-hydroxybutan-2-yl)phosphinic acid
• 化学式: C17H27N8O7P
• 分子量: 486.4
• InChiKey: XYNVLEQHASUONU-OTEKMBDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  200
• 氢给体数：
  5
• 氢受体数：
  13

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140148502A1

  公开（公告）日：2014-05-29

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE TREATMENT OF OTIC DISEASES AND CONDITIONS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150050354A1

  公开（公告）日：2015-02-19

  The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of otic diseases or conditions.
• ENZYMES AND POLYMERASES FOR THE SYNTHESIS OF RNA
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150211039A1

  公开（公告）日：2015-07-30

  The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.