(3R,5S)-2-benzyl-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopiperidine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,5S)-2-benzyl-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopiperidine-1-carboxylic acid
• 化学式: C₁₉H₂₆N₂O₅
• 分子量: 362.4
• InChiKey: ABLOWHLJARGOGC-XSDATEAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
  申请人：Incyte Corporation

  公开号：US20150057265A1

  公开（公告）日：2015-02-26

  The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

  本公开描述了呋喃和噻吩吡啶羧酰胺化合物，以及它们的组合物和使用方法。这些化合物抑制Pim激酶的活性，并且在治疗与Pim激酶活性相关的疾病方面具有用处，例如癌症和其他疾病。
• THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
  申请人：Incyte Corporation

  公开号：US20140200227A1

  公开（公告）日：2014-07-17

  The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

  本公开描述了噻唑和吡啶羧酰胺衍生物，它们的组成以及使用方法。这些化合物抑制Pim激酶的活性，并且在治疗与Pim激酶活性相关的疾病方面具有用途，例如癌症和其他疾病。
• Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
  申请人：Incyte Corporation

  公开号：US10000507B2

  公开（公告）日：2018-06-19

  The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

  本公开描述了呋喃和噻吩吡啶羧酰胺化合物及其组合物和使用方法。这些化合物抑制 Pim 激酶的活性，可用于治疗与 Pim 激酶活性有关的疾病，包括癌症和其他疾病。
• Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
  申请人：Incyte Corporation

  公开号：US10265307B2

  公开（公告）日：2019-04-23

  The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

  本公开描述了噻唑和吡啶羧酰胺衍生物、其组合物和使用方法。这些化合物抑制 Pim 激酶的活性，可用于治疗与 Pim 激酶活性有关的疾病，包括癌症和其他疾病。
• Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
  申请人：Incyte Corporation

  公开号：US10828290B2

  公开（公告）日：2020-11-10

  The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

  本公开描述了噻唑和吡啶羧酰胺衍生物、其组合物和使用方法。 这些化合物抑制 Pim 激酶的活性，可用于治疗与 Pim 激酶活性有关的疾病，包括癌症和其他疾病。