N-甲基-N-[4-(哌啶-1-基甲基)苄基]胺 | 859915-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-甲基-N-[4-(哌啶-1-基甲基)苄基]胺
• 英文名称: N-methyl-1-[4-(piperidin-1-ylmethyl)phenyl]methanamine
• CAS: 859915-28-9
• 化学式: C₁₄H₂₂N₂
• mdl: MFCD08060622
• 分子量: 218.342
• InChiKey: VUAOEKGFLXNSAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(1-benzyl-1H-benzoimidazole-carbonyl)-amino]-acetic acid 、 N-甲基-N-[4-(哌啶-1-基甲基)苄基]胺 在 2-氯-1,3-二甲基氯化咪唑啉 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以96%的产率得到1-benzyl-N-(2-{methyl[4-(piperidin-1-ylmethyl)benzyl]amino}-2-oxoethyl)-1H-benzimidazole-2-carboxamide
  参考文献：
  名称：

  1-Benzylbenzimidazoles: The discovery of a novel series of bradykinin B1 receptor antagonists

  摘要：

  The design, synthesis, and structure-activity studies of a novel series of BK B-1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B-1 receptor were discovered. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.014

文献信息

• Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US11066420B2

  公开（公告）日：2021-07-20

  Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

  蛋白酪氨酸磷酸酶（PTPs）是新陈代谢和胰岛素信号传导的关键调节因子。作为胰岛素信号转导的负调控因子，低分子量蛋白酪氨酸磷酸酶（LMPTP）是胰岛素抵抗及相关疾病的靶标。本文描述了能够调节低分子量蛋白酪氨酸磷酸酶（LMPTP）活性水平的化合物和组合物，以及使用这些化合物和组合物的方法。
• INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US20200055875A1

  公开（公告）日：2020-02-20

  Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.
• 1-Benzylbenzimidazoles: The discovery of a novel series of bradykinin B1 receptor antagonists
  作者：Qin Guo、Jayaraman Chandrasekhar、David Ihle、David J. Wustrow、Bertrand L. Chenard、James E. Krause、Alan Hutchison、Dawn Alderman、Charles Cheng、Daniel Cortright、Daniel Broom、Mark T. Kershaw、Jean Simmermacher-Mayer、Yao Peng、Kevin J. Hodgetts

  DOI：10.1016/j.bmcl.2008.08.014

  日期：2008.9

  The design, synthesis, and structure-activity studies of a novel series of BK B-1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B-1 receptor were discovered. (C) 2008 Elsevier Ltd. All rights reserved.