(1R,5R)-2-methyl-1-propan-2-yl-2-azabicyclo[3.1.0]hexane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1R,5R)-2-methyl-1-propan-2-yl-2-azabicyclo[3.1.0]hexane
• 化学式: C₉H₁₇N
• 分子量: 139.24
• InChiKey: ZDCPJSLRBKENHC-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF
  申请人：Heffernan Michele L. R.

  公开号：US20140221332A1

  公开（公告）日：2014-08-07

  Compounds that modulate GluR5 activity and methods of using the same are disclosed.

  本发明揭示了调节GluR5活性的化合物及其使用方法。
• SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
  申请人：Genentech, Inc.

  公开号：US20180118680A1

  公开（公告）日：2018-05-03

  The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.