(6-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-acetic acid methyl ester | 172405-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (6-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-acetic acid methyl ester
• 英文别名: Methyl 2-[6-[[(4-methoxyphenyl)-diphenylmethyl]amino]purin-9-yl]acetate
• CAS: 172405-50-4
• 化学式: C₂₈H₂₅N₅O₃
• 分子量: 479.538
• InChiKey: GZSNAKBUZQCHJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  91.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (6-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-acetic acid methyl ester 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以94%的产率得到[N⁶-(4-methoxytrityl)-adenin-9-yl]-acetic acid
  参考文献：
  名称：

  Synthesis of polyamide nucleic acids (PNAs) using a novel Fmoc/Mmt protecting-group combination

  摘要：

  The preparation of 9-Fluorenylmethoxycarbonyl(Fmoc) protected building blocks for the synthesis of polyamide nucleic acids (PNAs) is described. Use of 4-Methoxyphenyldiphenylmethyl (Mmt)-protecting groups for the exocyclic amino function of the nucleobases enhances the solubility of the monomers and allows final deprotection by mild acid treatment. The novel synthetic route is exemplified by the synthesis of heptameric and octameric PNAs.

  DOI：

  10.1016/0960-894x(96)00082-0
• 作为产物：
  描述：

  腺嘌呤 在 N-乙基吗啉 、 sodium hydride 作用下， 以 吡啶 为溶剂， 反应 3.0h， 生成 (6-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-acetic acid methyl ester
  参考文献：
  名称：

  Synthesis of polyamide nucleic acids (PNAs) using a novel Fmoc/Mmt protecting-group combination

  摘要：

  The preparation of 9-Fluorenylmethoxycarbonyl(Fmoc) protected building blocks for the synthesis of polyamide nucleic acids (PNAs) is described. Use of 4-Methoxyphenyldiphenylmethyl (Mmt)-protecting groups for the exocyclic amino function of the nucleobases enhances the solubility of the monomers and allows final deprotection by mild acid treatment. The novel synthetic route is exemplified by the synthesis of heptameric and octameric PNAs.

  DOI：

  10.1016/0960-894x(96)00082-0

文献信息

• US6121418A
  申请人：——

  公开号：US6121418A

  公开（公告）日：2000-09-19
• US6316595B1
  申请人：——

  公开号：US6316595B1

  公开（公告）日：2001-11-13
• Synthesis of polyamide nucleic acids (PNAs) using a novel Fmoc/Mmt protecting-group combination
  作者：G. Breipohl、J. Knolle、D. Langner、G. O'Malley、E. Uhlmann

  DOI：10.1016/0960-894x(96)00082-0

  日期：1996.3

  The preparation of 9-Fluorenylmethoxycarbonyl(Fmoc) protected building blocks for the synthesis of polyamide nucleic acids (PNAs) is described. Use of 4-Methoxyphenyldiphenylmethyl (Mmt)-protecting groups for the exocyclic amino function of the nucleobases enhances the solubility of the monomers and allows final deprotection by mild acid treatment. The novel synthetic route is exemplified by the synthesis of heptameric and octameric PNAs.