Propan-2-yl 3-methylsulfinylpropanoate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: Propan-2-yl 3-methylsulfinylpropanoate
• 英文别名: propan-2-yl 3-methylsulfinylpropanoate
• 化学式: C₇H₁₄O₃S
• 分子量: 178.25
• InChiKey: AESIZYCJKJILTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  62.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Process for Preparing Atazanavir Sulphate
  申请人：CIPLA LIMITED

  公开号：US20160002166A1

  公开（公告）日：2016-01-07

  The present invention relates to a process for the preparation of Compound (A): wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substantially pure Compound (A), and to Compound (A) devoid of mesityl oxide impurity. Mesityl oxide has the following formula:

  本发明涉及一种制备化合物(A)的过程：其中该过程包括将阿扎那韦碱（化合物（II））与硫酸在两种或多种溶剂的组合中接触，并分离化合物（A）。本发明还涉及基本纯净的化合物（A）以及不含二甲基苯酮杂质的化合物（A）。二甲基苯酮的化学式为：
• PROCESS FOR PREPARING ATAZANAVIR SULPHATE
  申请人：Cipla Limited

  公开号：EP2956439B1

  公开（公告）日：2019-01-09
• US9890121B2
  申请人：——

  公开号：US9890121B2

  公开（公告）日：2018-02-13
• [EN] PROCESS FOR PREPARING ATAZANAVIR SULPHATE<br/>[FR] PROCÉDÉ DE PRODUCTION DE SULFATE D'ATAZANAVIR
  申请人：CIPLA HOUSE

  公开号：WO2014125270A1

  公开（公告）日：2014-08-21

  The present invention relates to a process for the preparation of Compound (A): (Formula (A)) wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substantially pure Compound (A), and to Compound (A) devoid of mesityl oxide impurity. Mesityl oxide has the following formula: (Formula (B)).