4-[1-[[1-[(3-Methylphenyl)methyl]piperidine-2-carbonyl]amino]cyclopropyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[1-[[1-[(3-Methylphenyl)methyl]piperidine-2-carbonyl]amino]cyclopropyl]benzoic acid
• 英文别名: 4-[1-[[1-[(3-methylphenyl)methyl]piperidine-2-carbonyl]amino]cyclopropyl]benzoic acid
• 化学式: C₂₄H₂₈N₂O₃
• 分子量: 392.5
• InChiKey: RKFZEUMOSDGKGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS
  申请人：Borriello Manuela

  公开号：US20140243373A1

  公开（公告）日：2014-08-28

  There is described a group of novel cyclic amine derivative compounds having an EP 4 receptor agonistic activity. Specifically, the compounds according to the invention are provided with analgesic, antinflammatory, antiglaucoma activity, and also with anti-osteoporosis and antiulcerative activity. The present invention therefore relates to novel cyclic amine derivative compounds, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, inter alia for the treatment or alleviation of Prostaglandin E mediated diseases such as pain, glaucoma, ulcerative colitis and osteoporosis.

  本文描述了一组新型环胺衍生物化合物，具有EP4受体激动活性。具体来说，根据本发明的化合物具有镇痛、抗炎、抗青光眼活性，以及抗骨质疏松和抗溃疡活性。因此，本发明涉及新型环胺衍生物化合物、其制备方法、含有它们的药物组合物以及它们作为药物的用途，其中包括用于治疗或缓解前列腺素E介导的疾病，如疼痛、青光眼、溃疡性结肠炎和骨质疏松症。
• US9120824B2
  申请人：——

  公开号：US9120824B2

  公开（公告）日：2015-09-01