1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-2-methylidenepyrimidin-4-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-2-methylidenepyrimidin-4-one
• 英文别名: 1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-2-methylidenepyrimidin-4-one
• 化学式: C₁₄H₂₃N₂O₄P
• 分子量: 314.32
• InChiKey: JFPIQSIHPZCAQI-FMKGYKFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  82
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE
  申请人：MODERNA THERAPEUTICS

  公开号：US20140010861A1

  公开（公告）日：2014-01-09

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US20140255467A1
  申请人：——

  公开号：US20140255467A1

  公开（公告）日：2014-09-11
• MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160193299A1

  公开（公告）日：2016-07-07

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.