6,6,6-Triphenylhexanoic Acid | 33885-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 6,6,6-Triphenylhexanoic Acid
• 英文别名: 6,6,6-Triphenylhexanoic acid；6,6,6-triphenylhexanoic acid
• CAS: 33885-08-4
• 化学式: C₂₄H₂₄O₂
• 分子量: 344.453
• InChiKey: VKYUUJCJFNLIMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-Chlor-1,1,1-triphenylpentan 在 氢氧化钾 、 sodium iodide 作用下， 以 乙二醇 为溶剂， 生成 6,6,6-Triphenylhexanoic Acid
  参考文献：
  名称：

  Carbanions. XI. Reactions of 4-chloro-1,1,1-triphenylbutane, 5-chloro-1,1,1-triphenylpentane, and 1,1,1-triphenylethane with alkali metals. 1,4 and 1,5 Migration of phenyl

  摘要：

  DOI：

  10.1021/jo00974a001

文献信息

• Compounds for the treatment of metabolic disorders
  申请人：Hodge L. Kevin

  公开号：US20060247309A1

  公开（公告）日：2006-11-02

  Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, artherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 0, 1, 2, 4 or 5; q is 0 or 1; t is 0 or 1; R 2 is alkyl from 1 to 3 carbon atoms; R 3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by or 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloaldyl having from 3 to 6 ring carbon atoms wherein the cycloaldyl is unsubstitited or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compounds of formula (I) by a ring carbon; and R 1 is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R 1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).

  本发明揭示了用于治疗各种代谢性疾病的药剂，例如胰岛素抵抗综合征、糖尿病、高脂血症、脂肪肝病、消瘦症、肥胖症、动脉粥样硬化和动脉硬化。其中，公式（I）中，n为1或2；m为0、1、2、4或5；q为0或1；t为0或1；R2为1至3个碳原子的烷基；R3为氢、卤素、1至3个碳原子的烷基或1至3个碳原子的烷氧基；A为苯基，未取代或被1或2个基取代，所述基选择自：卤素、1或2个碳原子的烷基、全氟甲基、1或2个碳原子的烷氧基和全氟甲氧基；或者为具有3至6个环碳原子的环烷基，其中所述环烷基未取代或1或2个环碳原子被独立地甲基或乙基单取代；或者为具有1或2个从N、S和O中选择的环杂原子的5或6元杂环芳基，所述杂环芳基通过一个环碳原子与公式（I）中余下的化合物共价结合；R1为氢或1或2个碳原子的烷基。或者，当R1为氢时，生物活性剂可以是公式（I）化合物的药学上可接受的盐。
• COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Hodge L. Kirvin

  公开号：US20080015254A1

  公开（公告）日：2008-01-17

  Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 4, or 5; q is 0 or 1; t is 0 or 1; R 2 is alkyl having from 1 to 3 carbon atoms; R 3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and R 1 is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R 1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula I.

  本发明揭示了用于治疗各种代谢性疾病的药物，例如胰岛素抵抗综合征、糖尿病、高脂血症、脂肪肝病、消瘦、肥胖症、动脉硬化和动脉粥样硬化等。其中n为1或2；m为0、1、2、4或5；q为0或1；t为0或1；R2为具有1至3个碳原子的烷基；R3为氢、卤素、具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基；A为苯基，未取代或取代为1或2个选自：卤素、具有1或2个碳原子的烷基、全氟甲基、具有1或2个碳原子的烷氧基和全氟甲氧基的基团；或具有3至6个环碳原子的环烷基，其中环烷基未取代或一个或两个环碳原子独立地被甲基或乙基单取代；或具有1或2个选自N、S和O的环杂芳基，且所述杂芳环通过一个环碳原子与化合物的其余部分共价结合；以及R1为氢或具有1或2个碳原子的烷基。或者，当R1为氢时，化合物I的药物活性剂可以是其药学上可接受的盐。
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