6-(4-chlorophenyl)-1-tosylpiperidine-2,4-dione | 1186526-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 6-(4-chlorophenyl)-1-tosylpiperidine-2,4-dione
• 英文别名: 6-(4-Chlorophenyl)-1-(4-methylphenyl)sulfonylpiperidine-2,4-dione
• CAS: 1186526-44-2
• 化学式: C₁₈H₁₆ClNO₄S
• 分子量: 377.848
• InChiKey: ZBFFPOBPRXPNQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  79.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4-氯苯亚甲基)-4-甲苯磺酰胺 以 甲苯 为溶剂， 反应 4.0h， 生成 6-(4-chlorophenyl)-1-tosylpiperidine-2,4-dione
  参考文献：
  名称：

  Facile Synthesis of δ-Amino-β-ketoesters and Piperidinediones via a Vinylogous Mannich-Type Reaction of Brassard-Type Diene with Aldimines without Catalyst

  摘要：

  The vinylogous Mannich reaction of N-tosyl-aldimines with Brassard diene proceeds at room temperature under catalyst-free conditions smoothly to give gamma-amino-beta-ketoesters (4b-l) in good to excellent yields, which are easily converted to piperidinediones at higher temperature. The two-step reactions could be combined in a one-pot process with toluene as a solvent and without the use of any catalyst for direct synthesis of piperidinediones (5).

  DOI：

  10.1080/00397910902730846

文献信息

• Facile Synthesis of <font>δ</font>-Amino-<font>β</font>-ketoesters and Piperidinediones via a Vinylogous Mannich-Type Reaction of Brassard-Type Diene with Aldimines without Catalyst
  作者：Chun-Ling Gu、Li Liu、Dong Wang、Yong-Jun Chen

  DOI：10.1080/00397910902730846

  日期：2009.7.21

  The vinylogous Mannich reaction of N-tosyl-aldimines with Brassard diene proceeds at room temperature under catalyst-free conditions smoothly to give gamma-amino-beta-ketoesters (4b-l) in good to excellent yields, which are easily converted to piperidinediones at higher temperature. The two-step reactions could be combined in a one-pot process with toluene as a solvent and without the use of any catalyst for direct synthesis of piperidinediones (5).