2,5-diphenyl-2H-pyrazole-3,4-dione-4-thiazol-2-ylhydrazone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2,5-diphenyl-2H-pyrazole-3,4-dione-4-thiazol-2-ylhydrazone
• 英文别名: 2,5-Diphenyl-2H-pyrazol-3,4-dion-4-thiazol-2-ylhydrazon；(4E)-2,5-diphenyl-4-(1,3-thiazol-2-ylhydrazinylidene)pyrazol-3-one
• 化学式: C₁₈H₁₃N₅OS
• 分子量: 347.4
• InChiKey: SSDCCUULADRYJO-CAPFRKAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Prolylhydroxylase inhibitors and methods of use
  申请人：Cornell University

  公开号：EP2891649A1

  公开（公告）日：2015-07-08

  Compounds for inhibiting hypoxia inducible factor (HIF) prolyl-4-hydroxylases (PHDs) having the general formula: Methods of using these and related compounds for treating a patient having a condition that would benefit from inhibiting HIF PHD are also described herein.

  用于抑制具有通式的低氧诱导因子（HIF）脯氨酰-4-羟化酶（PHD）的化合物： 本文还描述了使用这些化合物和相关化合物治疗因抑制 HIF PHD 而患病的患者的方法。
• PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE
  申请人：Cornell University

  公开号：EP2536709A2

  公开（公告）日：2012-12-26
• ANTIBIOTIC COMPOSITIONS AND RELATED SCREENING METHODS
  申请人：Wong Chi-Huey

  公开号：US20090203641A1

  公开（公告）日：2009-08-13

  Moenomycin inhibits bacterial growth by clocking the transglycosylase activity of class A penicillin-binding proteins (PBPs), which are key enzymes in bacterial cell wall synthesis. The binding affinities of moenomycin A with various truncated PBPs were compared showing that the transmembrane domain is important for moenomycin binding. Full-length class-A PBPs from 16 bacterial species were produced, and their binding activities showed a correlation with the antimicrobial activity of moenomycin against Enterococcus faecalis and Staphylococcus aureus . Moreover, a fluorescence anisotropy-based high-throughput assay was developed and used successfully for identification of transglycosylase inhibitors.
• US8916540B2
  申请人：——

  公开号：US8916540B2

  公开（公告）日：2014-12-23
• US9505741B2
  申请人：——

  公开号：US9505741B2

  公开（公告）日：2016-11-29