1-(1,2-Dimethyl-propylcarbamoyl)-piperidine-4-carboxylic acid | 188854-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1,2-Dimethyl-propylcarbamoyl)-piperidine-4-carboxylic acid
• 英文别名: 1-[(3-Methylbutan-2-yl)carbamoyl]piperidine-4-carboxylic acid；1-(3-methylbutan-2-ylcarbamoyl)piperidine-4-carboxylic acid
• CAS: 188854-33-3
• 化学式: C₁₂H₂₂N₂O₃
• mdl: MFCD11164927
• 分子量: 242.318
• InChiKey: YNYILTBSHBDORR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  光气 、 1,2-甲基丙胺 、 生成 1-(1,2-Dimethyl-propylcarbamoyl)-piperidine-4-carboxylic acid
  参考文献：
  名称：

  Solid phase synthesis of ureas of secondary amines via carbamoyl chloride

  摘要：

  Secondary amines attached to a solid support such as the Wang resin can be converted to the corresponding carbamoyl chlorides by treatment with phosgene or triphosgene, Further reaction of the resulting carbamoyl chlorides with primary or secondary amines affords ureas in high yield and chemical purity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00245-1

文献信息

• Solid phase synthesis of ureas of secondary amines via carbamoyl chloride
  作者：Gary T. Wang、Yuanwei Chen、Sheldon Wang、Richard Sciotti、Thomas Sowin

  DOI：10.1016/s0040-4039(97)00245-1

  日期：1997.3

  Secondary amines attached to a solid support such as the Wang resin can be converted to the corresponding carbamoyl chlorides by treatment with phosgene or triphosgene, Further reaction of the resulting carbamoyl chlorides with primary or secondary amines affords ureas in high yield and chemical purity. (C) 1997 Elsevier Science Ltd.