Compounds of formula (I), wherein Z = cyclopentyl. cyclopropylmethyl, -CH3; R' = -CH3, CHF2, X= formula (II) (III) (IV) (V) Y = - CO; -C=O(CH2), -CH(OH)-CH2, -CH2-C=O, -CH2-CH2-C=O; -CH2-CH(OH)-CH2, -CH2- CH(OCOR1)-CH2 NR2 = -N(CH2-CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1 = optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.
化合物的
化学式(I),其中Z = 环戊基,环丙甲基,-
CH3;R' = - ,
CHF2,X =
化学式(II)(III)(IV)(V),Y = -CO;-C=O(
CH2),-CH(OH)- ,- -C=O,- - -C=O;- -CH(OH)- ,- -CH(OCOR1)- ,NR2 = -N( - OH)2,
化学式(VI)(VII)(VIII)(IX)(X)(XI),R1 = 可选择地取代的C1-C8烷基,可选择地取代的芳基;可选择地取代的芳基烷基,优选C1-C3烷基,更优选 ;以及其对映体,异构体和药学上可接受的盐;这些化合物具有PDE4D抑制活性,可用作治疗痴呆症,特别是阿尔茨海默病,并改善记忆的药物。