dipotassium;peroxide

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属有机物
• 英文名称: dipotassium;peroxide
• 化学式: K2O2
• 分子量: 110.195
• InChiKey: XXQBEVHPUKOQEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.37
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 副作用

Dermatotoxin - 皮肤烧伤。

Dermatotoxin - Skin burns.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的呕吐反射且不流口水，用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。不要试图中和，因为可能会发生放热反应。在去污后，用干燥的、无菌的敷料覆盖皮肤烧伤……。/氧化剂/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Oxidizers/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于昏迷、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。一旦出现上呼吸道梗阻的迹象，可能需要尽早进行气管插管。使用带有气囊面罩的呼吸囊进行正压通气技术可能有益。监测心率和必要时治疗心律失常...。开始静脉输液，使用5%葡萄糖盐水/生理盐水： "保持开放"，最低流速...。如果出现低血容量的迹象，使用乳酸钠林格液。注意液体过载的迹象。考虑使用药物治疗肺水肿...。对于伴有低血容量征象的低血压，谨慎给予液体。注意液体过载的迹象...。使用丙美卡因盐酸协助眼部冲洗...。/氧化剂/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in, respiratory arrest. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Oxidizers/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

过氧化物应立即从皮肤上冲洗掉，以防止刺激。在眼睛接触的情况下，应立即用大量清水冲洗眼睛，并寻求医疗帮助。如果是腐蚀性刺激物，如甲基乙基过氧化酮，延迟处理可能导致失明。如果不慎吞咽，也应寻求医疗帮助。如果出现过敏反应，应避免进一步接触。/过氧化物，有机和无机/

Peroxides should be washed promptly from the skin to prevent irritation. In the case of eye contact, the eyes should be flushed immediately with large amounts of water, and medical attention should be obtained. Delay in the case of corrosive irritants such as methyl ethyl ketone peroxide can result in blindness. Medical attention should also be obtained in case of accidental ingestion. If sensitization occurs, further contact should be avoided. /Peroxides, Organic and Inorganic/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

如果摄入有毒；避免吸入粉尘或与皮肤或眼睛接触。

TOXIC IF INGESTED; AVOID BREATHING DUST OR CONTACT WITH SKIN OR EYES.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  2,3,4,5-四苯基吡咯 、 dipotassium;peroxide 生成 苯甲酰胺
  参考文献：
  名称：

  MUNEER, MOHAMMED;KAMAT, PRASHANT V.;GEORGE, MANAPURATHU V., CAN. J. CHEM., 68,(1990) N, C. 969-975

  摘要：

  DOI：

文献信息

• Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
  申请人：Sui Zhihua

  公开号：US20050113402A1

  公开（公告）日：2005-05-26

  The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.

  本发明涉及化合物式（I）或（II）的新型吡咯吡啶酮衍生物：以及含有这些化合物的药物组合物，以及它们用于治疗性功能障碍的用途。
• NICOLAOU K. C.; MAGOLDA R. L.; SIPIO W. J.; BARNETTE W. E.; LYSENKO Z.; J+, J. AMER. CHEM. SOC., 1980, 102, NO 11, 3784-3793
  作者：NICOLAOU K. C.、 MAGOLDA R. L.、 SIPIO W. J.、 BARNETTE W. E.、 LYSENKO Z.、 J+

  DOI：——

  日期：——
• ASHOK, KONDA;KAMAT, PRASHANT V.;GEORGE, MANAPURATHU V., RES. CHEM. INTERMEDIATES, 13,(1990) N, C. 203-220
  作者：ASHOK, KONDA、KAMAT, PRASHANT V.、GEORGE, MANAPURATHU V.

  DOI：——

  日期：——
• PAQUETTE, LEO A.;FRIEDRICH, DIRK;ROGERS, ROBIN D., J. ORG. CHEM., 56,(1991) N2, C. 3841-3849
  作者：PAQUETTE, LEO A.、FRIEDRICH, DIRK、ROGERS, ROBIN D.

  DOI：——

  日期：——
• SMITH, AMOS B. (III);KONOPELSKI, JOSEPH P.;WEXLER, BARRY A.;SPRENGELER, P+, J. AMER. CHEM. SOC., 113,(1991) N, C. 3533-3542
  作者：SMITH, AMOS B. (III)、KONOPELSKI, JOSEPH P.、WEXLER, BARRY A.、SPRENGELER, P+

  DOI：——

  日期：——