lithium;hydride

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属有机物
• 英文名称: lithium;hydride
• 化学式: HLi
• 分子量: 8.0
• InChiKey: SRTHRWZAMDZJOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.88
• 重原子数：
  1
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

毒理性

• 毒性总结

鉴定和使用：氢化锂是一种柔软的银白色金属，它与水反应并在液氨中溶解。它用于制造聚烯烃塑料的催化剂；在飞机和导弹的燃料中也有使用。它在冶金中用作脱气剂、脱氧剂、脱硫剂；在非铁金属中用作晶粒细化剂。氢化锂还用作丁基锂聚合催化剂的化学中间体；在航空航天用途的铝合金或镁合金中也有使用。人类暴露和毒性：氢化锂会导致严重的眼睛和皮肤烧伤。在提取锂矿、制备各种锂化合物、焊接、钎焊、搪瓷和使用氢化锂的过程中，可能会发生工业暴露于锂。动物研究：没有找到动物研究资料。

IDENTIFICATION AND USE: Lithium hydride is a soft silver -white metal which reacts with water and is soluble in liquid ammonia.It is used in the manufacture of catalysts for polyolefin plastics; in fuels for aircraft, missiles. It is used in metallurgy, as degasifier, deoxidizer, desulfurizer; as grain refiner in non-ferrous metals. Used as a chemical intermediate for butyllithium polymerization catalyst; in alloys with aluminum or magnesium for aerospace uses. HUMAN EXPOSURE AND TOXICITY: Lithium hydride causes severe eye and skin burns. Industrial exposures to lithium may occur during extraction of lithium from its ores, preparation of various lithium compounds, welding, brazing, enameling, and from the use of lithium hydrides. ANIMAL STUDIES: No animal studies could be located.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

所有暴露途径均可能产生严重的局部影响。

Serious local effects by all routes of exposure.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

吸入，吞食，皮肤和/或眼睛接触

inhalation, ingestion, skin and/or eye contact

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 症状

眼睛刺激，皮肤刺激；眼睛、皮肤烧伤；口腔、食道烧伤（如果摄入）；恶心；肌肉抽搐；精神混乱；视力模糊

irritation eyes, skin; eye, skin burns; mouth, esophagus burns (if ingested); nausea; muscle twitches; mental confusion; blurred vision

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 吸入症状

咳嗽。喉咙痛。灼热感。恶心。呕吐。呼吸困难。

Cough. Sore throat. Burning sensation. Nausea. Vomiting. Shortness of breath.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

反应信息

• 作为反应物：
  描述：

  2-[2-(4-Chlorophenyl)ethoxy]acetic acid 、 lithium;hydride 以to give 1.6 g (43%) of 2-[2-(4-chlorophenyl)-ethoxy]ethanol in the form of an oil which的产率得到2-[2-(4-chlorophenyl)-ethoxy]ethanol
  参考文献：
  名称：

  Substituted phenoxy-aminopropanols

  摘要：

  描述了公式##STR1##中R为3或4个碳原子的支链烷基，R.sup.1为氢，卤素或较低的烷基，R.sup.2和R.sup.3，独立地为氢，卤素，较低的烷基，较低的烷氧基或较低的烷硫基，以及其药学上可接受的酸加盐。还描述了它们的制备过程以及含有它们的药物制剂。公式I的化合物及其盐具有心脏选择性β-肾上腺素受体阻滞活性和降压活性。

  公开号：

  US04649160A1

文献信息

• TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS
  申请人：Davies David Evan

  公开号：US20100137282A1

  公开（公告）日：2010-06-03

  Tricyclic nitrogen containing compounds and their use as antibacterials. Z 1 and Z 2 are independently selected from CH and N.

  三环氮含化合物及其作为抗菌剂的用途。Z1和Z2分别选择自CH和N。
• Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US04906755A1

  公开（公告）日：1990-03-06

  The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(3H)-ones and related compounds. The compounds are prepared from the appropriate carboxylic acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.

  本发明涉及一组六氢-8-羟基-2,6-甲基-2H-喹噁啉-3（3H）-酮及其相关化合物的酯类。这些化合物是通过适当的羧酸和醇经过标准程序制备的，或者在立体因素显著的情况下，可以使用一种利用超酸的重金属盐的新工艺。所涉及的化合物在治疗偏头痛和类似疾病以及细胞毒性药物引起的呕吐方面是有用的。
• Pyrimidofuroxans, their preparation and their use
  申请人：Cassella AG

  公开号：US05382585A1

  公开（公告）日：1995-01-17

  The present invention relates to pyrimidofuroxans of the general formula I ##STR1## in which A denotes ##STR2## where in each case the nitrogen atom is bonded via the C-4 and the carbon atom via the C-3 of the furoxan ring and the R radicals are defined as indicated in Claim 1, processes for their preparation and their use for the control and prevention of disorders of the cardiovascular system, in particular for the control and prevention of angina pectoris, and for the treatment of erectile dysfunctions.

  本发明涉及一般式I的嘧啶并呋喃氧化物：##STR1## 其中A表示##STR2## 在每种情况下，氮原子通过呋喃氧化物环的C-4键和碳原子通过C-3键结合，R基团的定义如权利要求书1所示，以及其制备过程和用于控制和预防心血管系统疾病，特别是用于控制和预防心绞痛以及治疗勃起功能障碍的用途。
• Benzo(B)thiophenes
  申请人：Parcor

  公开号：US04157399A1

  公开（公告）日：1979-06-05

  The present invention relates to new derivatives of 2-phenyl -benzo(b)thiophene mono- or disubstituted on the nitrogen atom of formula ##STR1## in which X.sup.1 to X.sup.9 which are identical or different are hydrogen, alkyl having up to 3 carbon atoms, chlorine, bromine, methoxy or methylthio, R.sup.1 is hydrogen, alkyl having up to 8 carbon atoms, optionally chlorinated or methoxylated, phenyl optionally chlorinated or methoxylated, aralkyl having in all up to 9 carbon atoms, optionally chlorinated or methoxylated on the phenyl nucleus, R.sup.2 is hydrogen, phenyl, Or a radical of the formula ##STR2## in which A is two hydrogen atoms or one oxygen atom and R.sup.3 can assume the same meanings as given for R.sup.1, the meanings assumed by R.sup.1 and R.sup.3 being independent from one another, or R.sup.1 and R.sup.2 together form the radical of a Schiff base of formula .dbd.CH--R.sup.4 (III) in which R.sup.4 is not hydrogen, but can otherwise assume the same meanings as R.sup.3, or the group ##STR3## forms the radical of a heterocyclic secondary amine. The invention also relates to the acid addition salts of the above compounds, notably those which are pharmaceutically compatible. The compounds of formula I are useful in normalizing the blood lipid value.

  本发明涉及2-苯基-苯并(b)噻吩的新衍生物，其在氮原子上单取代或双取代的化合物，其化学式为##STR1##其中，X.sup.1至X.sup.9相同或不同，为氢、具有最多3个碳原子的烷基、氯、溴、甲氧基或甲硫基，R.sup.1为氢、具有最多8个碳原子、可选氯化或甲氧基化的烷基、可选氯化或甲氧基化的苯基、总共最多有9个碳原子的芳基烷基，在苯环上可选氯化或甲氧基化，R.sup.2为氢、苯基或式中的基团##STR2##其中，A为两个氢原子或一个氧原子，R.sup.3可以假定与R.sup.1给出的相同含义，R.sup.1和R.sup.3的含义是相互独立的，或R.sup.1和R.sup.2一起形成式的席夫碱的基团.dbd.CH--R.sup.4(III)，其中R.sup.4不是氢，但可以假定与R.sup.3相同的含义，或者##STR3##组成杂环二级胺的基团。本发明还涉及上述化合物的酸加成盐，特别是那些具有药物相容性的化合物。式I的化合物在规范化血脂值方面是有用的。
• Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones
  申请人：——

  公开号：US20030176700A1

  公开（公告）日：2003-09-18

  A one-step process for preparing 2-pyridylamino-pyrido[2,3-d]pyrimidines of Formula II 1 wherein Ar is aryl, R′ and R″ are hydrogen, alkyl, halogen, or phenyl, and R 2 is alkyl.

  一步法制备化合物II1，其化学式为2-吡啶基氨基吡啶[2,3-d]嘧啶，其中Ar为芳基，R′和R″为氢、烷基、卤素或苯基，R2为烷基。