(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine maleate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine maleate
• 英文别名: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;but-2-enedioic acid
• 化学式: C23H24FNO7
• 分子量: 445.4
• InChiKey: AEIUZSKXSWGSRU-RVXRQPKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR
  申请人：DREYFUS Nicolas Jacques Francois

  公开号：US20100261762A1

  公开（公告）日：2010-10-14

  A serotonin and norepinephrine reuptake inhibitor of the formula: its uses, and methods for its preparation are described.

  一种谷胺酸和去甲肾上腺素的再摄取抑制剂的配方：描述了其用途和制备方法。
• Paroxetine cholate or cholic acid derivative salts, and composition comprising paroxetine and cholic acid or derivative thereof
  申请人：Lee Joon Sang

  公开号：US20060063747A1

  公开（公告）日：2006-03-23

  Disclosed herein is a paroxetine cholate or cholic acid derivative salt and a composition comprising paroxetine and cholic acid or a derivative thereof. Further disclosed is a pharmaceutical composition comprising the paroxetine salt or the composition. The pharmaceutical composition can be formulated into an oral preparation for swallowing without water as an orally disintegrating tablet for paroxetine.

  本文披露了帕罗西汀胆酸盐或胆酸衍生物盐以及包含帕罗西汀和胆酸或其衍生物的组合物。进一步披露了包含帕罗西汀盐或该组合物的药物组合物。该药物组合物可以制成口服制剂，作为帕罗西汀的口服崩解片，可直接吞咽而无需水。
• Process for the production of paroxetine
  申请人：——

  公开号：US20020151716A1

  公开（公告）日：2002-10-17

  The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses butanol and toluene as the system.

  使用由脂肪醇和烃类共溶剂组成的溶剂体系可以使帕罗西汀的合成更加方便。该溶剂体系特别适用于帕罗西汀苯基氨基甲酸酯的水解反应，最好使用丁醇和甲苯作为该体系的组成部分。
• Paroxetine maleate
  申请人：SmithKline Beecham plc

  公开号：US20030028027A1

  公开（公告）日：2003-02-06

  Paroxetine maleate and its preparation and use in the treatment and prevention of inter alia depression.

  帕罗西汀盐酸盐及其制备和用于治疗和预防抑郁症等疾病。
• [EN] PROCESS TO PRODUCE PAROXETINE<br/>[FR] PROCEDE DE PREPARATION DE PAROXETINE
  申请人：SYNTHON BV

  公开号：WO2002066466A1

  公开（公告）日：2002-08-29

  The present invention relates to a method for preparing paroxetine of the formula (1) and pharmaceutically suitable salts thereof, comprising the hydrolysis, using a hydrolysing substance, of paroxetine phenyl carbamate of the formula (3) in a solvent composition comprising a sovent which is able to at least partially dissolve the hydrolysing substance.

  本发明涉及一种制备公式（1）的帕罗西汀及其药用盐的方法，包括使用水解物质对公式（3）的帕罗西汀苯基氨甲酰基进行水解，在溶剂组成中使用至少部分溶解水解物质的溶剂。