7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonic acid | 91575-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonic acid
• 英文别名: 7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid；7-fluoro-2,1,3-benzoxadiazole-4-sulfonate；7-fluorobenzofurazan-4-sulfonic acid；4-fluoro-7-sulfobenzofurazan；2,1,3-Benzoxadiazole-4-sulfonic acid, 7-fluoro-
• CAS: 91575-54-1
• 化学式: C₆H₃FN₂O₄S
• 分子量: 218.165
• InChiKey: BXHVBQRYTWNRSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonic acid 在 氨 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以91%的产率得到4-Amino-2,1,3-benzoxadiazole-7-sulfonate
  参考文献：
  名称：

  Uchiyama, Seiichi; Santa, Tomofumi; Fukushima, Takeshi, Journal of the Chemical Society. Perkin Transactions 2 (2001), 1998, # 10, p. 2165 - 2173

  摘要：

  DOI：

文献信息

• ENCAPSULATED COMPOSITION FOR BINDING ALDEHYDES IN THE STOMACH
  申请人：BIOHIT OYJ

  公开号：US20160022620A1

  公开（公告）日：2016-01-28

  The present invention relates to non-toxic composition containing, as active compounds, one or more aldehyde-binding compounds, such as L- or D-cysteine, N-acetyl cysteine, and the pharmaceutically acceptable salts thereof, and optionally one or more further active compounds selected from sulphites and xylitol, the composition being used for decreasing the risk of a subject contracting cancer of the stomach, and indirectly of the small intestine and the large intestine. The composition is formulated into a controlled-release formulation consisting of granules contained in a capsule.

  本发明涉及一种无毒组合物，其包含一种或多种醛结合化合物作为活性化合物，例如L-或D-半胱氨酸、N-乙酰半胱氨酸和其药学上可接受的盐，以及可选的一种或多种进一步的活性化合物，选自亚硫酸盐和木糖醇，该组合物用于降低受试者患胃癌的风险，间接地降低小肠和大肠癌的风险。该组合物被配制成一种控制释放配方，由胶囊中含有颗粒组成。
• METHOD OF DETECTION, SEPARATION AND IDENTIFICATION FOR EXPRESSED TRACE PROTEIN/PEPTIDE
  申请人：Imai, Kazuhiro

  公开号：EP1705482A2

  公开（公告）日：2006-09-27

  A method of detection, separation and identification for expressed trace protein/peptide; and a system therefor. There is provided a method of detecting, separating and identifying a minute amount of expressed protein and/or peptide, characterized in that a fluorescent derivative of protein and/or peptide contained in a test subject sample having been labeled with a fluorescence reagent is applied to HPLC; a fluorescent fraction is collected and subjected to enzymatic hydrolysis; mass-spectrometry of the resultant fluorescence-labeled fragments and non-fluorescence-labeled fragments is carried out; and the thus obtained ion molecular weight information on each of the fragments is collated with an available protein and/or peptide fragment database to thereby accomplish a structural analysis. Further, there is provided an identification system therefor.

  一种检测、分离和鉴定表达的微量蛋白质/肽的方法及其系统。本发明提供了一种检测、分离和鉴定微量表达蛋白和/或肽的方法，其特征在于：将检测对象样品中含有的用荧光试剂标记的蛋白和/或肽的荧光衍生物应用于高效液相色谱法；收集荧光馏分并进行酶水解；对由此产生的荧光标记片段和非荧光标记片段进行质谱分析；将由此获得的每个片段的离子分子量信息与现有的蛋白质和/或肽片段数据库进行核对，从而完成结构分析。此外，还为此提供了一种识别系统。
• チオール基含有ペプチド・蛋白質の超高感度定量方法
  申请人：——

  公开号：JP2003050236A

  公开（公告）日：2003-02-21

  (57)【要約】\n【課題】 チオール基含有ペプチド・蛋白質をフェムトモルレベルで定量することが可能なチオール基含有ペプチド・蛋白質の超高感度定量方法を提供する。\n【解決手段】 界面活性剤存在下、４−フルオロ−７−スルホベンゾフラザン，アンモニウム塩によりチオール基含有ペプチド・蛋白質のチオール基を蛍光ラベル化し、高速液体クロマトグラフィーにより定量することを特徴とするチオール基含有ペプチド・蛋白質の超高感度定量方法。

  (57) [摘要] Јn[问题] 提供一种在微摩尔水平上对含硫醇基的肽和蛋白质进行定量的超灵敏方法。\在表面活性剂存在的情况下，用 4-氟-7-磺酸基苯并呋喃铵盐对含硫醇基的肽/蛋白质的硫醇基进行荧光标记，然后用高效液相色谱法对硫醇基进行定量。超灵敏的含硫醇基肽/蛋白质定量检测方法，其特点是在活化剂存在的情况下，用 4-氟-7-磺酸基苯并呋喃铵盐对含硫醇基肽/蛋白质的硫醇基进行荧光标记。
• HUMAN METHIONINE SYNTHASE REDUCTASE: CLONING, AND METHODS FOR EVALUATING RISK OF NEURAL TUBE DEFECTS, CARDIOVASCULAR DISEASE, AND CANCER
  申请人：——

  公开号：US20030082676A1

  公开（公告）日：2003-05-01

  The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

  本发明的特征是一种编码蛋氨酸合成酶还原酶的新型基因。本发明还具有一种检测高同型半胱氨酸血症可能性增加，进而检测神经管缺陷、心血管疾病或癌症可能性增加或减少的方法。本发明还具有治疗和/或降低心血管疾病、癌症或神经管缺陷风险的治疗方法。本发明还提供了人类蛋氨酸合成酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。
• Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube deffects, cardiovascular disease, cancer and Down's Syndrome
  申请人：Gravel A. Roy

  公开号：US20050191701A1

  公开（公告）日：2005-09-01

  The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

  本发明的特征是一种编码蛋氨酸合成酶还原酶的新型基因。本发明还具有一种检测高同型半胱氨酸血症可能性增加，进而检测神经管缺陷、心血管疾病、唐氏综合症或癌症可能性增加或减少的方法。本发明还具有治疗和/或降低心血管疾病、唐氏综合症、癌症或神经管缺陷风险的治疗方法。本发明还提供了人类蛋氨酸合成酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。