1-[2-[(3R)-3-(3,4-dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)pyrrolidin-3-yl]ethyl]-4-phenylpiperidine-4-carboxamide;hydron;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[2-[(3R)-3-(3,4-dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)pyrrolidin-3-yl]ethyl]-4-phenylpiperidine-4-carboxamide;hydron;chloride
• 化学式: C34H40Cl3N3O5
• 分子量: 677.1
• InChiKey: DAYXLOOGUORCMH-WAQYZQTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.13
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  94.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Emulsion formulations of an NK-1 receptor antagonist and uses thereof
  申请人：Heron Therapeutics, Inc.

  公开号：US10624850B2

  公开（公告）日：2020-04-21

  Disclosed herein are novel pharmaceutical formulations of a neurokinin-1 (NK-1) receptor antagonist suitable for parenteral administration including intravenous administration. Also included are formulations including both the NK-1 receptor antagonist and dexamethasone sodium phosphate. The pharmaceutical formulations are stable oil-in-water emulsions for non-oral treatment of emesis and are particularly useful for treatment of subjects undergoing highly emetogenic cancer chemotherapy.

  本文公开了一种神经激肽-1（NK-1）受体拮抗剂的新型药物制剂，适合肠外给药，包括静脉给药。还包括同时含有 NK-1 受体拮抗剂和地塞米松磷酸钠的制剂。这些药物制剂是稳定的水包油乳剂，用于非口服治疗呕吐，尤其适用于治疗正在接受高致呕吐癌症化疗的患者。
• TRICYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2824106B1

  公开（公告）日：2016-11-23
• SUTURES AND ANTI-SCARRING AGENTS
  申请人：Angiotech Pharmaceuticals, Inc.

  公开号：EP1978930A2

  公开（公告）日：2008-10-15
• PHARMACEUTICAL COMPOSITION COMPRISING ANTIEMETIC COMPOUNDS AND POLYORTHOESTER
  申请人：Heron Therapeutics, Inc.

  公开号：EP2931253A1

  公开（公告）日：2015-10-21
• electrical devices, anti-scarring agents, and therapeutic compositions
  申请人：Hunter William L.

  公开号：US20090280153A1

  公开（公告）日：2009-11-12

  Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the devices are implanted within an animal.