1-(Methanesulfinyl)-3,3-dimethylbutan-2-one | 64084-17-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: 1-(Methanesulfinyl)-3,3-dimethylbutan-2-one
• 英文别名: 3,3-dimethyl-1-methylsulfinylbutan-2-one
• CAS: 64084-17-9
• 化学式: C₇H₁₄O₂S
• 分子量: 162.25
• InChiKey: USJXTVWHVHBGEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  53.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pesticidal Arylpyrrolidines
  申请人：Mihara Jun

  公开号：US20120129854A1

  公开（公告）日：2012-05-24

  The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the yield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.

  本发明涉及芳基吡咯烷化合物，这些化合物展现出卓越的杀虫效果，并且可用于农用化学品领域或生产兽医药品。这些化合物由公式（I）表示：其中各个取代基在说明书中有定义。
• Pesticidal arylpyrrolidines
  申请人：Görgens Ulrich

  公开号：US20100216792A1

  公开（公告）日：2010-08-26

  The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.

  该发明涉及具有优异杀虫功效的芳基吡咯烷化合物，可以用于农药领域或兽医药领域。该化合物由式(I)表示：其中各自的取代基在说明书中定义。
• Carbamate, Ester, and Ketone Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239919A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R 12 or R 13 on the A group is a carbamate, ester, or ketone substituent (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  本文提供了包含式I的补体因子D抑制剂的化合物、使用方法和制备方法，或其药学上可接受的盐或组合物，其中A基团上的R12或R13是一个氨基甲酸酯、酯或酮取代基（R32）。所述抑制剂靶向因子D，能够在替代补体途径的早期和关键点抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。这些因子D抑制剂能够减少过度激活补体，这与某些自身免疫、炎症和神经退行性疾病、缺血再灌注损伤和癌症有关。
• Verfahren zur Herstellung von Sulfiden
  申请人：BASF Aktiengesellschaft

  公开号：EP0068371A1

  公开（公告）日：1983-01-05

  Herstellung von Sulfiden durch Umsetzung von Sulfoxiden mit Hydrazin- oder Hydroxylaminderivaten oder ihren quartären Salzen. Die nach dem Verfahren der Erfindung herstellbaren Sulfide sind wertvolle Ausgangsstoffe für die Herstellung von Pharmazeutika, Schädlingsbekämpfungsmitteln und Farbstoffen.

  通过硫醚与肼或羟胺衍生物或其季盐反应生产硫化物。 通过本发明工艺生产的硫化物是生产药品、杀虫剂和染料的重要起始原料。
• CARBAMATE, ESTER, AND KETONE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20170298085A1

  公开（公告）日：2017-10-19

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R 12 or R 13 on the A group is a carbamate, ester, or ketone substituent (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.