1,2,3,4-Tetramethyl-3-pyrazolin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 1,2,3,4-Tetramethyl-3-pyrazolin-5-one
• 英文别名: 1,2,4,5-tetramethylpyrazol-3-one
• 化学式: C₇H₁₂N₂O
• 分子量: 140.18
• InChiKey: CXRYULZRMNCUBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基乙酰乙酸乙酯 、 1,2-二甲基肼 生成 1,2,3,4-Tetramethyl-3-pyrazolin-5-one
  参考文献：
  名称：

  KATRIZKY, ALAN R.;BARCZYNSKI, PIOTR;OSTERCAMP, DARYL L., J. CHEM. SOC. PERKIN TRANS.,(1987) N 8, 969-975

  摘要：

  DOI：

文献信息

• 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS
  申请人：FORUM Pharmaceuticals Inc.

  公开号：US20150274706A1

  公开（公告）日：2015-10-01

  1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not limited to, those associated with cognitive deficits or schizophrenic symptoms.

  本文描述了抑制磷酸二酯酶10的1,2-二取代杂环化合物。同时还描述了该化合物的制备方法、制药组合物、制药制剂以及在治疗哺乳动物，包括人类的中枢神经系统（CNS）疾病和其他可能影响CNS功能的疾病中的制药用途。这些疾病包括但不限于与认知缺陷或精神分裂症状相关的神经、神经退行性和精神疾病。
• KATRIZKY, ALAN R.;BARCZYNSKI, PIOTR;OSTERCAMP, DARYL L., J. CHEM. SOC. PERKIN TRANS.,(1987) N 8, 969-975
  作者：KATRIZKY, ALAN R.、BARCZYNSKI, PIOTR、OSTERCAMP, DARYL L.

  DOI：——

  日期：——
• STEREO IMAGE PRINT AND METHOD OF PRODUCING THE SAME
  申请人：FUJIFILM CORPORATION

  公开号：US20130120676A1

  公开（公告）日：2013-05-16

  Provided is a stereo image print observable without polarized glasses, having a transparent support; first and second laminate disposed on a surface, respectively, of the transparent support, each laminate having an image layer satisfying condition (1) and a protective layer having at least one layer satisfying condition (2), the image layer and the protective layer being disposed in this order from the transparent support side: (1) each image layer has a dichroic image including pixels for a left eye and pixels for a right eye arranged in a predetermined array, each pixel having at least one kind of horizontally aligned dichroic dye, and absorption axes of the dichroic images in the first and the second laminates are orthogonal to each other, (2) the protective layer has an in-plane retardation value (Re) 10 mm or less for visible light.
• POLARIZING FILM, DISPLAY DEVICE AND PRODUCTION PROCESS THEREOF
  申请人：Morishima Shinichi

  公开号：US20130070899A1

  公开（公告）日：2013-03-21

  A polarizing film comprising a substrate, and a photo alignment film and a light absorption anisotropic film laminated on the substrate in this order, wherein the light absorption anisotropic film has a content ratio of 30% by mass or less of a liquid crystalline non-colorable low molecular weight compound and is obtained by fixing the alignment of a dichroic dye composition comprising at least one nematic liquid crystalline azo dichroic dye; in X-ray diffraction measurement thereof, diffraction peaks derived from periodic structure along a vertical direction to the alignment axis are present, the period indicated by at least one of the diffraction peaks is 3.0 to 15.0A and an intensity of the diffraction peak does not show a maximum value in the range of ±70° of the film normal line direction in a plane vertical to the alignment axis.
• US8466148B2
  申请人：——

  公开号：US8466148B2

  公开（公告）日：2013-06-18