1-(4-azido-2,6-difluorophenyl)-4-piperidinone | 565459-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-azido-2,6-difluorophenyl)-4-piperidinone
• 英文别名: 1-(4-Azido-2,6-difluorophenyl)-piperidin-4-one；1-(4-azido-2,6-difluorophenyl)piperidin-4-one
• CAS: 565459-92-9
• 化学式: C₁₁H₁₀F₂N₄O
• 分子量: 252.223
• InChiKey: JDEPXFQBBSFDCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  34.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(4-azido-2,6-difluorophenyl)-4-piperidinone 在 吡啶 、 盐酸羟胺 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以75%的产率得到1-(4-azido-2,6-difluoro-phenyl)-4-piperidin-4-one oxime
  参考文献：
  名称：

  [EN] TRIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS
  [FR] NOUVEAUX COMPOSES TRIAZOLIQUES, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  公开号：

  WO2005035528A3
• 作为产物：
  描述：

  1-(4-氨基-2,6-二氟苯基)-4-哌啶酮 在 盐酸 、 sodium nitrite 、 sodium azide 、 sodium acetate 作用下， 反应 1.0h， 以55%的产率得到1-(4-azido-2,6-difluorophenyl)-4-piperidinone
  参考文献：
  名称：

  [EN] TRIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS
  [FR] NOUVEAUX COMPOSES TRIAZOLIQUES, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  公开号：

  WO2005035528A3

文献信息

• [EN] Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)<br/>[FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE CONCENTRANT LA MELANINE (MCH1R)
  申请人：BIOVITRUM AB

  公开号：WO2005051381A1

  公开（公告）日：2005-06-09

  The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  该发明涉及通式（I）的化合物，其中R0、R1、R2、R3、R4、R5、R6、R7、R8、R9、Ar和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、消旋体、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。
• NOVEL ANTIBACTERIAL COMPOUNDS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Das Jagattaran

  公开号：US20050113347A1

  公开（公告）日：2005-05-26

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及一种新型三唑化合物，其化学式为（I），其衍生物，类似物，互变异构体，区域异构体，旋转异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物以及含有它们的制药组合物。更具体地，本发明涉及一种新型三唑化合物，其一般式为（I），其衍生物，类似物，互变异构体，区域异构体，旋转异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物以及含有它们的制药组合物。
• Novel antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
  申请人：Das Jagattaran

  公开号：US20050209223A1

  公开（公告）日：2005-09-22

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及公式（I）的新型三唑类化合物及其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物和含有它们的制药组合物。更特别地，本发明涉及一般公式（I）的新型三唑及其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物和含有它们的制药组合物。
• Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Laboratories Limited

  公开号：US07202254B2

  公开（公告）日：2007-04-10

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及一种新型三唑类化合物，其化学式为（I），其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物以及包含它们的制药组合物。更具体地，本发明涉及一种新型三唑类化合物，其化学式为（I），其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物以及包含它们的制药组合物。
• NOVEL ANTIBACTERIAL COMPOUNDS:PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1467977A1

  公开（公告）日：2004-10-20