1,4-Bipiperidine-4-carboxamide | 41053-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,4-Bipiperidine-4-carboxamide
• 英文别名: 1-piperidin-4-ylpiperidine-4-carboxamide
• CAS: 41053-55-8
• 化学式: C₁₁H₂₁N₃O
• 分子量: 211.3
• InChiKey: FGXRMJQHFMLWDT-UHFFFAOYSA-N

物化性质

• 沸点：
  394.6±42.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 4-cyano-benzyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10336729B2

  公开（公告）日：2019-07-02

  The invention relates to new benzonitrile derivatives of the formula (I) wherein R1 to R3 and A are as defined in the description and Claims, to their medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明涉及式（I）（其中 R1 至 R3 和 A 如说明书和权利要求书中所定义）的新苯甲腈衍生物，涉及它们的药物、它们的治疗使用方法和含有它们的药物组合物。
• Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10730850B2

  公开（公告）日：2020-08-04

  The invention relates to new heteroaryl derivatives of the formula wherein X is selected from the group consisting of: N and CH; X is selected from the group consisting of: N and CF; (with the proviso that at least one of X1 and X2 is N), and A is as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明涉及式中 X 选自以下组成的组的新杂芳基衍生物：N和CH；X选自由下列各项组成的组X1和X2中至少有一个是N），A如说明书和权利要求书中所定义，本发明涉及它们作为药物的用途、治疗方法和含有它们的药物组合物。
• BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES
  申请人：UNIVERSITY OF FLORIDA

  公开号：EP0174342A1

  公开（公告）日：1986-03-19
• PYRIDINYLMETHYL CARBAMIMIDOYLCARBAMATE DERIVATIVES AND THEIR USE AS AOC3 INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3423436B1

  公开（公告）日：2020-09-16
• 4-CYANO-BENZYL CARBAMIMIDOYLCARBAMATE DERIVATIVES AND THEIR USE AS AOC3 INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20190077790A1

  公开（公告）日：2019-03-14

  The invention relates to new benzonitrile derivatives of the formula (I) wherein R 1 to R 3 and A are as defined in the description and Claims, to their medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.