Trimeperidin | 42325-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Trimeperidin
• 英文别名: (+/-)-1,2r,5t-trimethyl-4c-phenyl-4t-propionyloxy-piperidine; hydrochloride；(+/-)-1,2r,5t-Trimethyl-4c-phenyl-4t-propionyloxy-piperidin; Hydrochlorid；Trimeperidine hydrochloride；[(2S,4S,5R)-1,2,5-trimethyl-4-phenylpiperidin-4-yl] propanoate;hydrochloride
• CAS: 42325-78-0
• 化学式: C₁₇H₂₅NO₂*ClH
• 分子量: 311.852
• InChiKey: USGVEUCDHRWIRO-RECIXLKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.62
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PHARMACEUTICAL AGENT WITH ANTITUMORAL ACTIVITY
  申请人：KISLYAKOVA, Nonna Dmitrievna

  公开号：EP0609460A1

  公开（公告）日：1994-08-10

  The invention relates to medicine, in particular in experimental and clinical oncology and may be used for treatment of hormonosensitive tumors in women as well as in neglected cases at the loss of hormonosensitivity. The proposed pharmaceutical agent consists, in the case of treatment of hormonosensitive tumors at women, of a mechanical mixture of 2-4 g of DL-valine and a small nontherapeutic dose of 0.020-0.025 g of methyltestosterone, and, in the case of treatment of non-hormonosensitive tumors, of a mechanical mixture of 2-4 g of DL-valine, 0.005-0.010 g of methandrostenolone and 0.3-0.5 g of phtivazid. The technical result of using the proposed agent consists in that even in neglected cases the size of tumor decreases, sometimes up to complete resorption, the pain syndrome disappears, the life of incurable patients is substantially prolongated accompanied by a satisfactory subjective condition, or, sometimes, by the resorption of the tumor. The use of the agent is not followed by any toxic effects, it increases even the antitumor resistance of the organism in the form of normalization of hemopoiesis, weight gain, substantial increase of the working capacity. The absence of side-effects and complications allows the agent to be used under ambulant conditions.

  本发明涉及医学，特别是实验和临床肿瘤学，可用于治疗妇女对激素敏感的肿瘤，也可用于治疗被忽视的对激素失去敏感性的病例。在治疗对激素敏感的妇女肿瘤时，拟议的药剂由 2-4 克 DL-缬氨酸和 0.020-0.025 克甲基睾酮的小剂量非治疗性混合物组成；在治疗对激素不敏感的肿瘤时，拟议的药剂由 2-4 克 DL-缬氨酸、0.005-0.010 克甲雄孕酮和 0.3-0.5 克夫替瓦齐德的机械混合物组成。使用这种药剂的技术效果是，即使在被忽视的病例中，肿瘤也会缩小，有时甚至完全吸收，疼痛综合征消失，不治之症患者的寿命大大延长，同时主观状况令人满意，有时肿瘤也会吸收。使用这种药剂不会产生任何毒副作用，甚至会增强机体的抗肿瘤能力，表现为造血功能正常化、体重增加、工作能力大幅提高。由于没有副作用和并发症，该药物可在常人条件下使用。
• US4070494A
  申请人：——

  公开号：US4070494A

  公开（公告）日：1978-01-24
• US4192294A
  申请人：——

  公开号：US4192294A

  公开（公告）日：1980-03-11