2-pyrrolidin-1-yl-4,5-dihydro-oxazole | 65972-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-pyrrolidin-1-yl-4,5-dihydro-oxazole
• 英文别名: 4,5-dihydro-2-(1-pyrolidinyl)oxazoline；2-(Pyrrolidin-1-yl)-4,5-dihydro-1,3-oxazole；2-pyrrolidin-1-yl-4,5-dihydro-1,3-oxazole
• CAS: 65972-70-5
• 化学式: C₇H₁₂N₂O
• 分子量: 140.185
• InChiKey: MDZPLEIKJFFUEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  24.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrrolidone derivatives, oligomers and polymers
  申请人：NanoSynthons LLC

  公开号：US10968176B2

  公开（公告）日：2021-04-06

  Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.

  我们已经制备出了简单的有机结构、有机/无机聚合物和其他基质，所有这些基质都至少含有一个吡咯烷酮分子，并发现它们具有低毒性、低补体激活特性，可用于减少蛋白质与药物共轭物的相互作用，同时在用作注射组合物时可提高这些共轭物在体内的驻留时间；因此，这些化合物可在 PEG 化过程中用作 PEG 的替代品。令人惊奇的是，这些化合物还表现出独特的本征荧光（IF）或非传统荧光（NTF）特性，而这些特性目前还无法用传统的光化学和荧光范式来解释。这些化合物有多种应用，如细胞成像、基因转染、生物诊断、生物传感、荧光引导手术切除、给药、法医、环境诊断、矿物/宝石表征、假冒商品检测、与液体/水流有关的示踪研究、油田增强和诊断、防止光漂白、LED 显示屏增强等。
• Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands
  申请人：The Penn State Research Foundation

  公开号：US20010044546A1

  公开（公告）日：2001-11-22

  The invention is drawn to novel transition metal catalysts for the practical synthesis of important chiral molecules. The transition metal catalysts comprise chiral ligands based on chiral amine oxazolinyl ligands. The invention includes methods of making the catalysts, and methods of performing reactions using the catalysts.

  本发明涉及用于重要手性分子实际合成的新型过渡金属催化剂。过渡金属催化剂包括基于手性胺噁唑啉基配体的手性配体。本发明包括制造催化剂的方法和使用催化剂进行反应的方法。
• TRANSITION METAL-CATALYZED REACTIONS BASED ON CHIRAL AMINE OXAZOLINYL LIGANDS
  申请人：The Pennsylvania State University

  公开号：EP1030849A1

  公开（公告）日：2000-08-30
• AQUEOUS INKJET INK, AND METHOD FOR FORMING INKJET IMAGE
  申请人：Konica Minolta Holdings, Inc.

  公开号：EP2592120B1

  公开（公告）日：2017-08-02
• AQUEOUS INKJET INK AND METHOD FOR FORMING INKJET IMAGE
  申请人：Ikeda Masashi

  公开号：US20130106945A1

  公开（公告）日：2013-05-02

  Disclosed is an aqueous inkjet ink which may contain water, a pigment, an organic or an inorganic acid, an amine, a resin that has a higher pKa than the organic or the inorganic acid, and a cross-linking agent. The aqueous inkjet ink exhibits excellent abrasion resistance even in cases where the drying time is short, while having high bleeding resistance and high storage stability. Also disclosed is a method for forming an inkjet image.