3,3,5-Trimethyl-piperidin | 37832-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3,3,5-Trimethyl-piperidin
• 英文别名: 3,3,5-trimethyl-piperidine；3,3,5-Trimethylpiperidine
• CAS: 37832-46-5
• 化学式: C₈H₁₇N
• mdl: MFCD19218107
• 分子量: 127.23
• InChiKey: CDUQWBAPFRDIKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 3,3,5-Trimethyl-piperidin
  参考文献：
  名称：

  一些哌啶-甲基同系物的合成

  摘要：

  来自二和三甲基戊二酸，z。在某些情况下，通过改进的已知方法已经制备了相应的二甲基和三甲基戊二酸酐和酰亚胺，并且已经通过LiAlH将后者转化为以下哌啶-甲基同系物：3,5-二甲基-哌啶， 4、4-二甲基-哌啶，3，S-二甲基-哌啶，3,3,5-三甲基-哌啶和3,4,4-三甲基-哌啶。

  DOI：

  10.1002/hlca.19540370202

文献信息

• [EN] DOSING REGIMENS FOR CYCLIN‑DEPENDENT KINASE 7 (CDK7) INHIBITORS<br/>[FR] SCHÉMAS POSOLOGIQUES POUR INHIBITEURS DE LA KINASE 7 DÉPENDANTE DES CYCLINES (CDK7)
  申请人：SYROS PHARMACEUTICALS INC

  公开号：WO2022082056A1

  公开（公告）日：2022-04-21

  The present invention provides for the use of various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, stereoisomers, and isotopic forms thereof in treating a proliferative disease such as cancer in a patient. Administration of a compound or pharmaceutical composition at a dose and conforming to a dosing regimen described herein is expected to inhibit cyclin‑dependent kinase 7 (CDK7), and thereby, treat the cancer.

  本发明提供了使用各种组合物，包括式（I）或（Ia）的化合物或其一种，以及其药学上可接受的盐、立体异构体和同位素形式，用于治疗患者的增殖性疾病，如癌症。按照本文所述的剂量和给药方案给予化合物或药物组合预计能够抑制细胞周期依赖性激酶7（CDK7），从而治疗癌症。
• 1,2,4-Thiadazole compounds and use thereof
  申请人：Hara Hideki

  公开号：US20070004722A1

  公开（公告）日：2007-01-04

  The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R 1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene optionally substituted with one to four of R 2?, C4-C7 straight alkenylene optionally substituted with one to four of R 2?, ethylene-oxy-ethylene optionally substituted with one to four of R 4?, or ethylene-thio-ethylene optionally substituted with one to four of R 4?, R 2? represents a halogen atom, trifluoromethyl or C1-C4 alkyl, and R4 represents a fluorine atom or C1-C3 alkyl. The 1,2,4-thiadiazole compound has an excellent pests controlling activity, and can effectively control an pests such as insect pests, acarine pests and the like.

  本发明涉及一种由式（1）表示的式（I）的1,2,4-噻二唑化合物，其中R1?代表C3-C7炔基，X代表C4-C7直链烷基，可选地用一到四个R2?，C4-C7直链烯基，可选地用一到四个R2?，乙二醇基乙二醇，可选地用一到四个R4?，或者乙硫基乙二醇，可选地用一到四个R4?取代，R2?代表卤素原子、三氟甲基或C1-C4烷基，R4代表氟原子或C1-C3烷基。该1,2,4-噻二唑化合物具有优异的害虫控制活性，可以有效地控制昆虫害虫、螨虫等害虫。
• ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL
  申请人：Ihara Hideki

  公开号：US20100137372A1

  公开（公告）日：2010-06-03

  An isoxazoline compound represented by the formula (I): wherein the substituents are as defined in the description, has controlling activity against pests.

  一种异噁唑啉化合物，其化学式表示为（I）：其中取代基如描述中定义的那样，具有对害虫的控制活性。
• Isoxazoline Compounds and their Use in Pest Control
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2308858A1

  公开（公告）日：2011-04-13

  The present invention relates to an isoxazoline compound represented by the formula (1): wherein the substituents are as defined in the description, which has a controlling activity against pests.

  本发明涉及一种由式（1）表示的异噁唑啉化合物： 其中的取代基如描述中所定义，该化合物具有防治害虫的活性。
• 1,2,4-Thiadiazole Compounds and Pests Controlling Composition Containing the same
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2492265A1

  公开（公告）日：2012-08-29

  The present invention relates to a 1,2,4-thiadiazole compound of the formula (I): wherein R1 represents C3-C7 alkynyl; X represents C4-C7 straight alkylene optionally substituted with one to four of R2, C4-C7 straight alkenylene optionally substituted with one to four of R2, or ethylene-thioethylene optionally substituted with one to four of R4; R2 represents a halogen atom, trifluoromethyl or C1-C4 alkyl; and R4 represents a fluorine atom or C1-C3 alkyl. The 1,2,4-thiadiazole compound has an excellent pest controlling activity, and can effectively control pests such as insect pests, acarine pests and the like.

  本发明涉及一种式（I）的 1，2，4-噻二唑化合物： 其中 R1 代表 C3-C7 烷基；X 代表任选被 R2 的 1 至 4 个取代的 C4-C7 直烯基、任选被 R2 的 1 至 4 个取代的 C4-C7 直烯基或任选被 R4 的 1 至 4 个取代的乙烯-硫代乙烯基；R2 代表卤原子、三氟甲基或 C1-C4 烷基；R4 代表氟原子或 C1-C3 烷基。1,2,4-噻二唑化合物具有极佳的害虫防治活性，可有效防治害虫，如昆虫、螨类害虫等。