3-{[3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]amino}propan-1-ol | 816457-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-{[3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]amino}propan-1-ol
• 英文别名: 3-[3-(1-Tritylimidazol-4-yl)propylamino]propan-1-ol
• CAS: 816457-30-4
• 化学式: C₂₈H₃₁N₃O
• 分子量: 425.574
• InChiKey: CFVYNYSQXJSMAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  50.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-{[3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]amino}propan-1-ol 、 3-氨基-1-丙醇 、 三氟乙酸 生成 3-{(3-Amino-propyl)-[3-(1H-imidazol-4-yl)-propyl]-amino}-propan-1-ol; compound with trifluoro-acetic acid
  参考文献：
  名称：

  Parallel Supported Synthesis of Polyamine−Imidazole Conjugates

  摘要：

  A small collection of nine polyamine-imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via S(N)2 alkylation of methanesulfonates with amines. The final introduction of N-4-nitrobenzyloxycarbonyldiamines allowed easy purification of the cleaved compounds.

  DOI：

  10.1021/ol0480630
• 作为产物：
  描述：

  3-(1-trityl-1H-imidazol-4-yl)propyl methanesulfonate 、 3-氨基-1-丙醇 反应 6.0h， 以3.24 g的产率得到3-{[3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]amino}propan-1-ol
  参考文献：
  名称：

  Parallel Supported Synthesis of Polyamine−Imidazole Conjugates

  摘要：

  A small collection of nine polyamine-imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via S(N)2 alkylation of methanesulfonates with amines. The final introduction of N-4-nitrobenzyloxycarbonyldiamines allowed easy purification of the cleaved compounds.

  DOI：

  10.1021/ol0480630

文献信息

• Parallel Supported Synthesis of Polyamine−Imidazole Conjugates
  作者：Sylvie Picard、Myriam Le Roch、Jacques Renault、Philippe Uriac

  DOI：10.1021/ol0480630

  日期：2004.12.1

  A small collection of nine polyamine-imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via S(N)2 alkylation of methanesulfonates with amines. The final introduction of N-4-nitrobenzyloxycarbonyldiamines allowed easy purification of the cleaved compounds.