1,3-Dimethyl-4-piperidinemethanol | 101966-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,3-Dimethyl-4-piperidinemethanol
• 英文别名: (1,3-dimethylpiperidin-4-yl)methanol
• CAS: 101966-72-7
• 化学式: C₈H₁₇NO
• 分子量: 143.23
• InChiKey: DYFKIAKFHTWSOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
  申请人：Bosmans Rene Marie Andre Jean-Paul

  公开号：US20070037850A1

  公开（公告）日：2007-02-15

  The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 and R 2 taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C 1-6 alkyl; R 3 is hydrogen or halo; R 4 is hydrogen or C 1-6 alkyl; R 5 is hydrogen or C 1-6 alkyl; L is C 3-6 cycloalkyl, C 5-6 cycloalkanone, C 2-6 alkenyl, or L is a radical of formula -Alk-R 6 —, Alk-X—R 7 , -Alk-Y—C(═O)—R 9 , or -Alk-Y—C(═O)—NR 11 R 12 wherein each Alk is C 1-12 alkanediyl; and R 6 is hydrogen, cyano, C 1-6 alkylsulfonylamino, C 3-6 cycloalkyl, C 5-6 cycloalkanone, or a heterocyclic ringsystem; R 7 is hydrogen, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 3-6 cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO 2 or NR 8 ; said R 8 being hydrogen or C 1-6 alkyl; R 9 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxy or hydroxy; Y is NR 10 or a direct bond; said R 10 being hydrogen, or C 1-6 alkyl; R 11 and R 12 each independently are hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or R 11 and R 12 combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.

  本发明涉及化合物的公式（I），其立体化学异构体形式，其N-氧化物形式或其药学上可接受的酸加成盐，其中R1和R2共同形成以下式的双价基团，在所述双价基团中，一个或两个氢原子可以被C1-6烷基取代；R3是氢或卤素；R4是氢或C1-6烷基；R5是氢或C1-6烷基；L是C3-6环烷基，C5-6环烷酮，C2-6烯基，或L是以下式的基团-Alk-R6—，Alk-X—R7，-Alk-Y-C（═O）-R9，或-Alk-Y-C（═O）-NR11R12，其中每个Alk是C1-12烷二基；而R6是氢，氰基，C1-6烷基磺酰胺基，C3-6环烷基，C5-6环烷酮或杂环环系；R7是氢，C1-6烷基，羟基C1-6烷基，C3-6环烷基或杂环环系；X是O，S，SO2或NR8；其中R8是氢或C1-6烷基；R9是氢，C1-6烷基，C3-6环烷基，C1-6烷氧基或羟基；Y是NR10或直接键；其中R10是氢或C1-6烷基；R11和R12各自独立地是氢，C1-6烷基，C3-6环烷基，或R11和R12与氮原子结合可以形成选择性取代的吡咯烷基，哌啶基，哌嗪基或4-吗啉基环。公开了制备该产品的过程，包括该产品的制剂及其用作药物的用途，特别是用于治疗与胃排空障碍有关的疾病。
• Bicyclic Benzamides of 3-Or-4-Substituted 4-(Aminomethyl)-Piperidine Derivatives
  申请人：Bosmans Jean-Paul René Marie André

  公开号：US20120028987A1

  公开（公告）日：2012-02-02

  The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.

  本发明涉及式(I)化合物及其立体化学异构体、N-氧化物形式或药学上可接受的酸加成盐。公开了制备上述产品的过程、包含上述产品的配方以及它们作为药物的用途，特别是用于治疗与胃排空障碍有关的疾病。
• Catalyst and process for hydrogenating olefinically unsaturated compound
  申请人：JSR Corporation

  公开号：EP0974602B1

  公开（公告）日：2004-01-02
• US6291596B1
  申请人：——

  公开号：US6291596B1

  公开（公告）日：2001-09-18
• US7205410B2
  申请人：——

  公开号：US7205410B2

  公开（公告）日：2007-04-17