1-methyl-3H-pyrrolizine | 5044-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯嗪
• 英文名称: 1-methyl-3H-pyrrolizine
• 英文别名: 1-Methyl-3H-pyrrolizine
• CAS: 5044-54-2
• 化学式: C₈H₉N
• 分子量: 119.166
• InChiKey: JUYJNLNFBYIZMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-methyl-3H-pyrrolizine 在 正丁基锂 作用下， 以 正己烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of new elementsubstituted derivatives of 3H-pyrrolizines

  摘要：

  The anion of 3H-pyrrolizine was isolated as its lithium 2a and thallium salts 3 and the anion of 1-methyl-3H-pyrrolizine as its lithium salt 2b. Reaction of the lithium anions with Group 14 electrophiles led to a number of substituted derivatives of the 3H-pyrrolizine ring system. In the case of 2b it was shown that the number of isomers obtained was strongly dependent on the reaction solvent. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(97)00771-7

文献信息

• Process for producing 5-substituted oxazole compounds and 5-substituted imidazole compounds
  申请人：——

  公开号：US20040116711A1

  公开（公告）日：2004-06-17

  A process for producing heterocyclic compounds which are useful as pesticides, drugs, fungicidal materials or intermediates thereof. TosMIC is reacted with an aldehyde or an imino compound: 1) in a solvent mixture of an aprotic solvent with a protic solvent in the presence of a base, 2) in the presence of a phase-transfer catalyst and an inorganic base, or 3) in the presence of an inorganic base. Thus, a desired product can be efficiently obtained using a solution without isolating TosMIC which is irritating and unstable, has a low decomposition point and shows explosivity.

  一种生产用于杀虫剂、药物、杀真菌材料或其中间体的杂环化合物的方法。将TosMIC与醛或亚胺化合物反应：1）在无极性溶剂与有极性溶剂的溶剂混合物中，在碱的存在下，2）在相转移催化剂和无机碱的存在下，或3）在无机碱的存在下。因此，可以使用不需要隔离TosMIC的溶液高效地获得所需产品，TosMIC具有刺激性和不稳定性，具有低分解点并显示易爆性。
• PROCESS FOR PRODUCING 5-SUBSTITUTED OXAZOLE COMPOUNDS AND 5-SUBSTITUTED IMIDAZOLE COMPOUNDS
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1371649A1

  公开（公告）日：2003-12-17

  A process for producing heterocyclic compounds which are useful as pesticides, drugs, functional materials or intermediates thereof. TosMIC is reacted with an aldehyde or an imino compound (1) in a solvent mixture of an aprotic solvent with a protic solvent in the presence of a base, (2) in the presence of a phase-transfer catalyst and an inorganic base, or (3) in the presence of an organic base. Thus, a desired product can be efficiently obtained using a solution without isolating TosMIC which is irritating and unstable, has a low decomposition point and shows explosivility.

  一种生产可用作农药、药物、功能材料或其中间体的杂环化合物的工艺。(1)在碱存在下，(2)在相转移催化剂和无机碱存在下，或(3)在有机碱存在下，在钝溶剂和原生溶剂的混合溶剂中，TosMIC 与醛或亚胺化合物反应。因此，无需分离出刺激性强、不稳定、分解点低和易爆炸的 TosMIC，就可以使用溶液高效地获得所需的产品。
• PROCESS FOR PRODUCING 5-SUBSTITUTED OXAZOLE AND 1,5-DISUBSTITUTED IMIDAZOLE COMPOUNDS
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1371649B1

  公开（公告）日：2006-07-05
• US7102010B2
  申请人：——

  公开号：US7102010B2

  公开（公告）日：2006-09-05
• USRE40795E1
  申请人：——

  公开号：USRE40795E1

  公开（公告）日：2009-06-23